The present mini review discusses recent developments in the research of interfacial phenomena of fluorinated amphiphiles and focuses on applications utilizing the unique and manifold interfacial properties associated with fluorinated amphiphiles. Most notably, fluorinated amphiphiles form stable aggregates with often distinctively different morphologies than their non-fluorinated counterparts. Consequently, fluorinated surfactants found wide use in high-performance applications such as microfluidic-assisted screening. Additionally, their fluorine-specific behaviour at the solid/liquid interface such as the formation of superhydrophobic coatings after deposition on surfaces will be discussed. As fluorinated surfactants and perfluorinated materials in general pose a potential environmental thread recent development for their remediation based on their adsorption onto fluorinated surfaces will be evaluated.