259
Ion Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules

A. Kruve, K. Caprice, R. Lavendomme, J.M. Wollschläger, S. Schoder, H.V. Schröder, J.R. Nitschke, F.B.L. Cougnon, C.A. Schalley – 2019

A rapid screening method based on traveling-wave ion mobility spectrometry (TWIMS) combined with tandem mass spectrometry provides insight into the topology of interlocked and knotted molecules, even when they exist in complex mixtures such as interconverting dynamic combinatorial libraries. A TWIMS characterization of structure-indicative fragments generated by collision-induced dissociation (CID) together with a floppiness parameter defined merely based on parent and fragment ion arrival times provide a straightforward topology identification. To demonstrate its broad applicability, this approach is applied here six Hopf and two Solomon links, a trefoil knot, and a [3]catenate.

Title
259
Ion Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules
Author
A. Kruve, K. Caprice, R. Lavendomme, J.M. Wollschläger, S. Schoder, H.V. Schröder, J.R. Nitschke, F.B.L. Cougnon, C.A. Schalley
Date
2019-06-10
Identifier
DOI: 10.1002/anie.201904541
Citation
Angew. Chem. 2019, 131, 11446-11450; Angew. Chem. Int. Ed. 2019, 58, 11324-11328
Type
Text