Multi-stimuli responsive soft materials have shown great potential for the implementation of function such as selective drug delivery, logic gating, and directional transport. Starting with an overview of multi-stimuli responsive gels, different stimuli-responsive elements and strategies that are employed to implement multi-responsiveness are discussed. As two other examples for typical materials, multi stimuli-responsive thin films on surfaces and nanocarriers are also reviewed. The last part of the chapter discusses more sophisticated function of these materials and provides a perspective for potential future developments.