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MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange

Abualrous ET, Stolzenberg S, Sticht J, Wieczorek M, Roske Y, Günther M, Dähn S, Boesen BB, Martínez Calvo M, Biese C, Kuppler F, Medina-García A, Álvaro-Benito M, Höfer T, Noé F, Freund C – 2023

In this paper by Abualrous et al., catalyzed peptide exchange, a process that shapes T cell responses, is reported for 12 different MHC class II variants. Experimental approaches taken by the Freund laboratory are combined with a theoretical description by the Noe group. It is shown that the population of a transient state has predictive value for catalyzed exchange and that MHC class II dynamics correlates with the odds ratio for the autoimmune disease rheumatoid arthritis.

Title
MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange
Author
Abualrous ET, Stolzenberg S, Sticht J, Wieczorek M, Roske Y, Günther M, Dähn S, Boesen BB, Martínez Calvo M, Biese C, Kuppler F, Medina-García A, Álvaro-Benito M, Höfer T, Noé F, Freund C
Date
2023-05-08
Identifier
https://doi.org/10.1038/s41589-023-01316-3
Appeared in
Nature Chemical Biology
Language
eng
Type
Text