Department of Biology, Chemistry, Pharmacy

Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR" recruits C9ORF78 to regulate alternative splicing

A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein–protein interactions

The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling

A non-native C-terminal extension of the β’ subunit compromises RNA polymerase and Rho functions

Transcription complexes as RNA chaperones

CryoEM analysis of small plant biocatalysts at sub-2 A°
resolution

The molecular and phenotypic spectrum of CLCN4-related epilepsy

Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility

Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2

Differential Impact of Fluid Shear Stress and YAP/TAZ on BMP/TGF‐β Induced Osteogenic Target Genes

ActivinA Induced SMAD1/5 Signaling in an iPSC Derived EC
Model of Fibrodysplasia Ossificans Progressiva (FOP) Can Be Rescued by the
Drug Candidate Saracatinib

Left-handed DNA-PAINT for improved super-resolution imaging in the nucleus

Directed manipulation of membrane proteins by fluorescent magnetic nanoparticles

The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling

A skipping rope translocation mechanism in a widespread family of DNA repair helicases
Roske in Nucleic Acids Research

Loll in JACS: The Impression of a Nonexisting Catalytic Effect: The Role of CotB2 in Guiding the Complex Biosynthesis of Cyclooctat-9-en-7-ol

Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ

Neumann in EMBO Reports
Neumann, Heyd, Preußner - Alternative splicing coupled mRNA decay shapes
the temperature‐dependent transcriptome

Stricker in Journal of Cachexia, Sarcopenia and Muscle: Cell autonomous requirement of neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis

Hiepen, Mendes, Knaus in Cells:
"It Takes Two to Tango:
Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology"

Huang - Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis

Freund in Brain
Syntaxin-1B mutations reveal clear molecular disease mechanisms that translate into distinct neurophysiological phenotypes

Knaus in Bone
BMP signalling in a mechanical context – Implications for bone biology

Meinke et al, in eLife
Srsf10 and the minor spliceosome control
tissue-specific and dynamic SR protein expression

Tom Haltenhof et al. in Molecular Cell: A conserved kinase-based body
temperature sensor globally controls alternative splicing and gene
expression

Knaus-AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells

Hiepen-BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

Chakrabarti - Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

Loll - Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

Wahl - Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis

Freund - Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain

Stauber - A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength

F. De Bortoli - Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39

A. Neumann - Genome-wide identification of
alternative splicing events that regulate protein transport across the
secretory pathway

J. Sticht - FBP21’s C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase

R. Driller - Towards a comprehensive understanding of the
structural dynamics of a bacterial diterpene
synthase during catalysis

S. Stricker - Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury

B. Loll - Molecular insights into antibiotic resistance - how a binding protein traps albicidin

S. Stricker - Genome-wide strategies identify downstream target genes of connective tissue-associated transcription factors

Sigmar Stricker - Cooperation of BMP and IHH signaling in interdigital cell fate determination

Jan Wollenhaupt - Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2

B. Loll: Ketonization of Proline Residues in the Peptide Chains of Actinomycins by a 4-Oxoproline Synthase

B. Loll: Rhodococcus erythropolis Oleate Hydratase: a New Member in the Oleate Hydratase Family Tree