Research Groups

Bottanelli Group - Membrane trafficking

Stricker Lab - Biochemistry and Genetics

Chakrabarti Lab - mRNA-Metabolism

Knaus Lab - Signal Transduction

Wahl Lab - Structural Biochemistry

Ewers Lab - Membrane Biochemistry

Heyd Lab - RNA Biochemistry

Freund Lab - Protein Biochemistry
Image Credits

Francesca Bottanelli
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Sigmar Stricker
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Sutapa Chakrabarti
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Petra Knaus
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Markus Wahl
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Helge Ewers
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Florian Heyd
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Christian Freund
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Recent Research

Dimos et al in Microbial Cell Factories
Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol

Bergfort et al. in Nature Communications
A multi-factor trafficking site on the spliceosome remodeling enzyme BRR" recruits C9ORF78 to regulate alternative splicing

Jehle et al. in Molecular Systems Biology
A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein–protein interactions

Bergfort et al. in Nucleic Acids Research
The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling

Mittermeier et al. in Molecular Microbiology
A non-native C-terminal extension of the β’ subunit compromises RNA polymerase and Rho functions

Said & Wahl in Transcription
Transcription complexes as RNA chaperones

Dimos and Helmer in Acta Cryst. D
CryoEM analysis of small plant biocatalysts at sub-2 A°
resolution

He in Epilepsia
The molecular and phenotypic spectrum of CLCN4-related epilepsy

Lan et al. in Nature Communication
Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

Grass et al. in PNAS
Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility

Absmeier et al. in JBC
Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2

Reichenbach et al. in Advanced Biology
Differential Impact of Fluid Shear Stress and YAP/TAZ on BMP/TGF‐β Induced Osteogenic Target Genes

Knaus in Stem Cell Rev and Rep
ActivinA Induced SMAD1/5 Signaling in an iPSC Derived EC
Model of Fibrodysplasia Ossificans Progressiva (FOP) Can Be Rescued by the
Drug Candidate Saracatinib

Geertsema in Nature Biotechnology
Left-handed DNA-PAINT for improved super-resolution imaging in the nucleus

Li in Nature Communications
Directed manipulation of membrane proteins by fluorescent magnetic nanoparticles

Pei in Nature Communications
The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling

Roske in Nucleic Acids Research
A skipping rope translocation mechanism in a widespread family of DNA repair helicases
Roske in Nucleic Acids Research

Loll in JACS
Loll in JACS: The Impression of a Nonexisting Catalytic Effect: The Role of CotB2 in Guiding the Complex Biosynthesis of Cyclooctat-9-en-7-ol

Said in Science
Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ

Preussner in EMBO Reports
Neumann in EMBO Reports
Neumann, Heyd, Preußner - Alternative splicing coupled mRNA decay shapes
the temperature‐dependent transcriptome

Stricker in Journal of Cachexia, Sarcopenia and Muscle
Stricker in Journal of Cachexia, Sarcopenia and Muscle: Cell autonomous requirement of neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis

Hiepen in Cells
Hiepen, Mendes, Knaus in Cells:
"It Takes Two to Tango:
Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology"

Huang in Molecular Cell
Huang - Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis

Freund in Brain
Freund in Brain
Syntaxin-1B mutations reveal clear molecular disease mechanisms that translate into distinct neurophysiological phenotypes

Knaus in Bone
Knaus in Bone
BMP signalling in a mechanical context – Implications for bone biology

Meinke in eLife
Meinke et al, in eLife
Srsf10 and the minor spliceosome control
tissue-specific and dynamic SR protein expression

Haltenhof in Molecular Cell
Tom Haltenhof et al. in Molecular Cell: A conserved kinase-based body
temperature sensor globally controls alternative splicing and gene
expression

Knaus in MBC of the cell
Knaus-AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells

Hiepen in PLOS Biology
Hiepen-BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

Chakrabarti in Nature Communications
Chakrabarti - Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

Loll in Beilstein J Org Chem
Loll - Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

Wahl in Nucleic Acids Research
Wahl - Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis

Freund in Structure
Freund - Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain

Stauber in eLIFE
Stauber - A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength

DeBortoli in Nucleic Acids Research
F. De Bortoli - Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39

Neumann in Journal of Cell Science
A. Neumann - Genome-wide identification of
alternative splicing events that regulate protein transport across the
secretory pathway

Sticht in Biophysical Journal
J. Sticht - FBP21’s C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase

Driller in Nature Communications
R. Driller - Towards a comprehensive understanding of the
structural dynamics of a bacterial diterpene
synthase during catalysis

Stricker in Stem Cell Research
S. Stricker - Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury

Loll in Nature Communications
B. Loll - Molecular insights into antibiotic resistance - how a binding protein traps albicidin

Stricker in Development
S. Stricker - Genome-wide strategies identify downstream target genes of connective tissue-associated transcription factors

Stricker in PLoS ONE
Sigmar Stricker - Cooperation of BMP and IHH signaling in interdigital cell fate determination

Wollenhaupt in Biophysical Journal
Jan Wollenhaupt - Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2

Loll in ChemBioChem
B. Loll: Ketonization of Proline Residues in the Peptide Chains of Actinomycins by a 4-Oxoproline Synthase

Loll in ChemCatChem
B. Loll: Rhodococcus erythropolis Oleate Hydratase: a New Member in the Oleate Hydratase Family Tree
Image Credits

Dimos et al in Mircobial Cell Factories
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Bergfort et al. in Nature Communications
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A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein–protein interactions
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220223 Bergfort et al. in Nucleic Acids Research
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220222 Mittermeier et al. in Molecular Microbiology
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Transcription complexes as RNA chaperones
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220106-cover
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210810 He in Epilepsia
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Lan in Nature Communications
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Grass in PNAS
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210726 Absmeier in JBC
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Reichenbach
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Knaus-in-Stem-Cell-Rev-and-Rep
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Geertsema in Nature Biotechnology
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Li in Nature Communications
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210104 Pei in Nature Communications
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Roske in Nucleic Acids Research
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201208 Loll in JACS
Image Credit: JACS

Said in Science
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201123 Preussner in EMBO Reports
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Nf1
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Hiepen in Cell
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200930Huang
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Freund-in-Brain
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Knaus in Bone
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Meinke et al in eLife
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Haltenhof in Molecular Cell
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200201-Knaus in MBC of the cell
Image Credit: MBC of the cell

200114-Hiepen in PLOS Biol
Image Credit: PLOS

191108-Sutapa
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Loll in Beilstein J Org Chem
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091019-Wahl-Nucleic Acids Res
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190910-Freund
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190627-Stauber-eLIFE
Image Credit: T. Stauber

190416 Francesca PRPF39 structure
Image Credit: DeBortoli

neumann_zelle1-3
Image Credit: Alex Neumann

190212-Jana-Sticht-Feb-2019-a
Image Credit: Sticht/Biophysical Journal

Driller/Nature Communications
Image Credit: Driller/Nature Communications

070918-Stricker
Image Credit: Stricker/Stem Cell Research

180809-Loll
Image Credit: B. Loll/Nature Communications

080818-Stricker
Image Credit: S. Stricker/Development

070818-Stricker-PLoS
Image Credit: S. Stricker/PLoS one

online access
Image Credit: J. Wollenhaupt

online access
Image Credit: B. Loll

online access
Image Credit: B. Loll