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Major histocompatibility complex (MHC) class I and class II proteins: impact of polymorphism on antigen presentation

Abualrous, Esam T. and Sticht, Jana and Freund, Christian – 2021

The major histocompatibility complex (MHC) loci are amongst the most polymorphic regions in the genomes of vertebrates. In the human population, thousands of MHC gene variants (alleles) exist that translate into distinct allotypes equipped with overlapping but unique peptide binding profiles. Understanding the differential structural and dynamic properties of MHC alleles and their interaction with critical regulators of peptide exchange bears the potential for more personalized strategies of immune modulation in the context of HLA-associated diseases.

Title
MajorHistocompatability_Abualrous
Author
Abualrous, Esam T. and Sticht, Jana and Freund, Christian
Date
2021-05-27
Identifier
10.1016/j.coi.2021.04.009
Source(s)
Appeared in
Current Opinion in Immunology - Volume 70, 2021, pages 95-104
Language
eng
Type
Text