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Ion mobility-mass spectrometry as a tool to investigate protein–ligand interactions

Review on investigating protein-ligand interactions by IM-MS

News from May 15, 2017


Ion mobility-mass spectrometry (IM-MS) is apowerful tool for the simultaneous analysis of mass, charge,size, and shape of ionic species. It allows the characterizationof even low-abundant species in complex samples and istherefore particularly suitable for the analysis of proteins andtheir assemblies. In the last few years even complex and in-tractable species have been investigated successfully with IM-MS and the number of publications in this field is steadilygrowing. This trend article highlights recent advances inwhich IM-MS was used to study protein-ligand complexesand in particular focuses on the catch and release (CaR) strategy and collision-induced unfolding (CIU).

go to article DOI: 10.1007/s00216-017-0384-9

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