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652. Photo-responsive hydrogels based on a ruthenium complex: synthesis and degradation

S. Tavakkoli Fard, B. Thongrom, K. Achazi, G. Ma, R. Haag, C. C. Tzschucke – 2024

We report the synthesis of a photo responsive metallo-hydrogel based on a ruthenium(II) complex as a functional cross-linker. This metal complex contains reactive 4AAMP (= 4-(acrylamidomethyl)pyridine) ligands, which can be cleaved by light-induced ligand substitution. Ru[(bpy)2(4AAMP)2] cross-links 4-arm-PEG-SH macromonomers by thia-Michael-addition to the photocleavable 4AAMP ligand for the preparation of the hydrogel. Irradiation with green light at 529 nm leads to photodegradation of the metallo-hydrogel due to the ligand dissociation, which can be adjusted by adjusting the Ru[(bpy)2(4AAMP)2] concentration. The ligand substitution forming [Ru(bpy)2(L)2]2+ (L = H2O and CH3CN) can be monitored by 1H NMR spectroscopy and UV-visible absorption. The control of degradation by light irradiation plays a significant role in modulating the elasticity and stiffness of the light sensitive metallo-hydrogel network. The photo-responsive hydrogel is a viable substrate for cell cultures.

Title
652. Photo-responsive hydrogels based on a ruthenium complex: synthesis and degradation
Author
S. Tavakkoli Fard, B. Thongrom, K. Achazi, G. Ma, R. Haag, C. C. Tzschucke
Date
2024
Identifier
DOI: 10.1039/D3SM01232H
Source(s)
Citation
Soft Matter, 2024, Advance Article
Type
Text