572. One-pot gram-scale synthesis of a virucidal polymer:heparin-mimicking polymers for inhibition of herpes simplex virus 1
V. Ahmadi, C. Nie, E. Mohammadifar, K. Achazi, S. Wedepohl, Y. Kerkhoff, S. Block, K. Osterrieder, R. Haag – 2021
A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.