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567. In vitro efficacy of Artemisia extracts against SARS-CoV-2

C. Nie, J. Trimpert, S. Moon, R. Haag, K. Gilmore, B. B. Kaufer; P. H. Seeberger – 2021

Background Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Teas and drinks containing extracts of Artemisia annua and Artemisia afra have been widely used in Africa in efforts to prevent SARS-CoV-2 infection and fight COVID-19. Methods The plant extracts and Covid-Organics drink produced in Madagascar were tested for plaque reduction using both feline coronavirus and SARS-CoV-2 in vitro. Their cytotoxicities were also investigated. Results Several extracts as well as Covid-Organics inhibited SARS-CoV-2 and FCoV infection at concentrations that did not affect cell viability. Conclusions Some plant extracts show inhibitory activity against FCoV and SARS-CoV-2. However, it remains unclear whether peak plasma concentrations in humans can reach levels needed to inhibit viral infection following consumption of teas or Covid-Organics. Clinical studies are required to evaluate the utility of these drinks for COVID-19 prevention or treatment of patients.

Title
567. In vitro efficacy of Artemisia extracts against SARS-CoV-2
Author
C. Nie, J. Trimpert, S. Moon, R. Haag, K. Gilmore, B. B. Kaufer; P. H. Seeberger
Date
2021
Identifier
DOI: 10.1186/s12985-021-01651-8
Source(s)
Citation
Virol J., 2021, 18, 182
Type
Text