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557. Functional Surfactants for Molecular Fishing, Capsule Creation, and Single-Cell Gene Expression.

M. S. Chowdhury, X. Zhang, L. Amini, P. Dey, A. K. Singh, A. Faghani, M. S. Henneresse, R. Haag – 2021

Creating a single surfactant that is open to manipulation, while maintaining its surface activity, robustness, and compatibility, to expand the landscape of surfactant-dependent assays is extremely challenging. We report an oxidation-responsive precursor with thioethers and multiple 1,2-diols for creating a variety of functional surfactants from one parent surfactant. Using these multifunctional surfactants, we stabilize microfluidics-generated aqueous droplets. The droplets encapsulate different components and immerse in a bioinert oil with distinct interfaces where an azide-bearing surfactant allow fishing of biomolecules from the droplets, aldehyde-bearing surfactant allow fabrication of microcapsules, and hydroxyl-bearing surfactants, with/without oxidized thioethers, allow monitoring of single-cell gene expression. Creating multifunctional surfactants poses opportunities for broad applications, including adsorption, bioanalytics, catalysis, formulations, coatings, and programmable subset of emulsions.

Title
557. Functional Surfactants for Molecular Fishing, Capsule Creation, and Single-Cell Gene Expression.
Author
M. S. Chowdhury, X. Zhang, L. Amini, P. Dey, A. K. Singh, A. Faghani, M. S. Henneresse, R. Haag
Date
2021
Identifier
DOI: 10.1007/s40820-021-00663-x
Source(s)
Citation
Nano-Micro Lett., 2021, 13, 147
Type
Text