Springe direkt zu Inhalt

501. Reverse design of an influenza neutralizing spiky nano-inhibitor with a dual mode of action.

C. Nie, B. Parshad, S. Bhatia, C. Cheng, M. Stadtmüller, A. Oehrl, Y. Kerkhoff, T. Wolff, R. Haag – 2020

In this study, we demonstrate the concept of “topology-matching design” for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nanoparticle-based inhibitor (nano-inhibitor) that has a matched nanotopology to IAV virions and shows heteromultivalent inhibitory effects on hemagglutinin and neuraminidase. The synthesized nano-inhibitor can neutralize the viral particle extracellularly and block its attachment and entry to the host cells. The virus replication was significantly reduced by 6 orders of magnitude in the presence of the reverse designed nano-inhibitors. Even when used 24 hours after the infection, more than 99.999 % inhibition is still achieved, which indicates such a nano-inhibitor might be a potent antiviral for the treatment of influenza infection.

Title
501. Reverse design of an influenza neutralizing spiky nano-inhibitor with a dual mode of action.
Author
C. Nie, B. Parshad, S. Bhatia, C. Cheng, M. Stadtmüller, A. Oehrl, Y. Kerkhoff, T. Wolff, R. Haag
Date
2020
Identifier
DOI: 10.1002/anie.202004832
Source(s)
Citation
Angew. Chem. Int. Ed., 2020, 132 (36), 15662-15666
Type
Text