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30. Novel metal-ion-incorporated mussel-inspired poly(vinyl alcohol)-based polymer coating offers improved antibacterial activity andcellular mechanoresponse manipulation

L. Gao, Y. Hou, H. Wang, M. Li, L. Ma, Z. Chu, I. S. Donskyi, R. Haag – 2022

Cobalt (CoII) ions have been an attractive candidate for the biomedical modification of orthopedic implants for decades. However, limited research has been performed into how immobilized CoII ions affect the physical properties of implant devices and how these changes regulate cellular behavior. In this study we modified biocompatible poly(vinyl alcohol) with terpyridine and catechol groups (PVA-TP-CA) to create a stable surface coating in which bioactive metal ions could be anchored, endowing the coating with improved broad-spectrum antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as enhanced surface stiffness and cellular mechanoresponse manipulation. Strengthened by the addition of these metal ions, the coating elicited enhanced mechanosensing from adjacent cells, facilitating cell adhesion, spreading, proliferation, and osteogenic differentiation on the surface coating. This dual-functional PVA-TP-CA/Co surface coating offers a promising approach for improving clinical implantation outcomes.

Title
30. Novel metal-ion-incorporated mussel-inspired poly(vinyl alcohol)-based polymer coating offers improved antibacterial activity andcellular mechanoresponse manipulation
Author
L. Gao, Y. Hou, H. Wang, M. Li, L. Ma, Z. Chu, I. S. Donskyi, R. Haag
Date
2022
Identifier
DOI: 10.1002/anie.202201563
Source(s)
Citation
Angew. Chem. Int. Ed. Engl., 2022, 61, e2022015
Type
Text