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3. Synthesis and preliminary evaluation of novel [(Cp-R)M(CO)3] (M = Re, 99mTc) complexes as potent sigma-2 receptor ligands

D Li, X Wang, Winnie Deuther-Conrad, X Chen, M Cui, Joerg Steinbach, Peter Brust, BL Liu, HM Jia – 2013

Sigma-2 (σ 2) receptors have been proposed to be the progesterone receptor membrane component 1. Progress in cancer biology has revealed that (σ 2) receptors are over-expressed in many types of cancer. The expression of (σ 2) receptors is assumed to be a suitable biomarker of cellular proliferation in solid tumors . In our previous work, we used PB28 as lead compound to design novel 99m Tc cyclopentadienyl tricarbonyl complex as putative agent for (σ 2) receptor tumor imaging . In this abstract, RHM-1, another (σ 2) receptor selective ligand, was used as lead compound to design novel [(Cp-R) M (CO) 3](M= Re, 99m Tc) complexes as potent (σ 2) receptor ligands. Synthesis and preliminary evaluation of these complexes are reported.

Title
3. Synthesis and preliminary evaluation of novel [(Cp-R)M(CO)3] (M = Re, 99mTc) complexes as potent sigma-2 receptor ligands
Author
D Li, X Wang, Winnie Deuther-Conrad, X Chen, M Cui, Joerg Steinbach, Peter Brust, BL Liu, HM Jia
Date
2013
Citation
Journal of Labelled Compounds and Radiopharmaceuticals 56(2013), S383-S383
Type
Text