11. Direct visualization and identification of biofunctionalized nanoparticles using a magnetic atomic force microscope.
Block, S.*; Glöckl, G.; Weitschies, W.; Helm, C.A. – 2011
Because of its outstanding ability to image and manipulate single molecules, atomic force microscopy (AFM) established itself as a fundamental technique in nanobiotechnology.(1) We present a new modality that distinguishes single nanoparticles by the surrounding magnetic field gradient. Diamagnetic gold and superparamagnetic iron oxide nanoparticles become discernible under ambient conditions. Images of proteins, magnetolabeled with nanoparticles, demonstrate the first steps toward a magnetic analogue to fluorescence microscopy, which combines nanoscale lateral resolution of AFM with unambiguous detection of magnetic markers.
Title
11. Direct visualization and identification of biofunctionalized nanoparticles using a magnetic atomic force microscope.
Author
Block, S.*; Glöckl, G.; Weitschies, W.; Helm, C.A.
Date
2011
Identifier
10.1021/nl201312w
Citation
Nano Letters 2011, 11, 3587-3592