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Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding

P. Kiran, S. Kumari, J. Dernedde, R. Haag, S. Bhatia* – 2019

Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preference for hyperbranched polyglycerols in the case of MBL inhibitors, a clear advantage of ligand presentation on linear polyglycerol scaffolds was observed for DC-SIGN.

Title
Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
Author
P. Kiran, S. Kumari, J. Dernedde, R. Haag, S. Bhatia*
Date
2019
Identifier
DOI: 10.1039/C9NJ02018G
Source(s)
Citation
New J. Chem., 2019, 43, 16012-16016
Type
Text