Synthesis and lipase-catalyzed enzymatic enantioselective acylation studies on ethyl 4-aryl-3,4-dihydropyrimidin-2(1H)-ones
A. Prasad, P. Arya, S. Bhatia, R. K. Sharma, R. Singh, K. Brajendra, E. van der Eycken, R. Singh, C. E. Olsen, V. S. Parmar – 2009
A series of different analogs of 4-aryl-3,4-dihydropyrimidin-2(1H)-one have been synthesized and their biocatalytic resolution has been carried out using immobilized lipase CAL-L(A) (immobilized on accurel). The systematic one-step procedure is developed for the synthesis of optically enriched ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates 8a-d and acylated ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates 9a-e, 10a-e, 11b-d and 12a-e, by the enantioselective acylation of racemic ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates using CAL-L(A).
Title
Synthesis and lipase-catalyzed enzymatic enantioselective acylation studies on ethyl 4-aryl-3,4-dihydropyrimidin-2(1H)-ones
Author
A. Prasad, P. Arya, S. Bhatia, R. K. Sharma, R. Singh, K. Brajendra, E. van der Eycken, R. Singh, C. E. Olsen, V. S. Parmar
Date
2009
Source(s)
Citation
Indian J. Chem., 2009, 48B, 1738-1748.
Type
Text