Dr. rer. nat. Paul- Lennard Mendez
Paul completed his Master of Science in medical biotechnology at the Technische Universität Berlin in September 2019. He received a scholarship from the International Max-Planck Research School for Biology and Computation (IMPRS-BAC) and joined the Knaus Lab in October 2019. Paul defended his dissertation in 2023, earning the highest honors Summa cum Laude. His research has a strong focus on mechanotransduction and mechanically induced genetic changes in the vascular system. He uses a wide array of sequencing techniques, including ATAC-Seq, RNA-Seq, CUT&RUN-Seq and single cell sequencing methods to understand the molecular basis of atherosclerosis. Paul is also a visitng scientist at MDC/ BIH.
Biochemisches Blockpraktikum- Lipide und Membranen
Method Module: Growth Factor Signaling and Interplay with Cell Mechanics
Jatzlau J., Mendez PL., Altay A., Raaz L., Zhang Y, Sesver A., Reichenbach M., Mundlos S., Vingron M., Knaus P. BMP9 and Fluid Shear Stress Regulate Endothelial Chromatin Accessibility and Expression of SMAD Low Affinity Target Genes. PREPRINT.
Mendez PL, Obendorf L, Jatzlau J, Burdzinski W, Reichenbach M, Nageswaran V, Haghikia A, Stangl V, Hiepen C, Knaus P. Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes. BMC Biol. 2022 Sep 28. DOI: 10.1186/s12915-022-01396-y.
Mendez, P. L., Obendorf, L., Knaus, P. Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay. J. Vis. Exp. (175)
Reichenbach, M.; Mendez, P.-L.; da Silva Madaleno, C.; Ugorets, V.; Rikeit, P.; Boerno, S.; Jatzlau, J.; Knaus, P. Differential Impact of Fluid Shear Stress and YAP/TAZ on BMP/TGF‐β Induced Osteogenic Target Genes. Advanced Biology 2021.
Hiepen, C.; Mendez, P.-L.; Knaus, P. It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology. Cells 2020.