Dr. Felix Bredendiek
Institut für Pharmazie
It is assumed that incubation of methyltestestorone and different AAS with CYP1A2 and CYP1B1 results in 2-hydroxy-17‑methyltestosterone and 4-hydroxy-17‑methyltestosterone [oxymesterone]. The aim of my work is to monitor specific metabolic pathways with an newly developed SFC-ESI-QQQ-MS method in addition to the established GC-MS(/MS) and LC-MS(/MS) methods. As the expected metabolites are not available as reference material they must be synthesized prior to the analyses.Some of the metabolic products may also serve as long-term markers of an administration.