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Prof. Dr. Matthias F. Melzig:


Sehner SM, Melzig MF. Pharmazie. 2022 Jan 3;77(1):2-5. doi: 10.1691/ph.2022.1135. Fluorometric quantification of alkaloids in the homeopathic mother tinctures of Vinca minor L. and Fumaria officinalis L.

Olędzka A, Cichocka K, Woliński K, Melzig MF, Czerwińska ME. Nutrients. 2022 May 30;14(11):2287. doi: 10.3390/nu14112287. Potentially Bio-Accessible Metabolites from an Extract of Cornus mas Fruit after Gastrointestinal Digestion In Vitro and Gut Microbiota Ex Vivo Treatment.

Bunse M, Daniels R, Gründemann C, Heilmann J, Kammerer DR, Keusgen M, Lindequist U, Melzig MF, Morlock GE, Schulz H, Schweiggert R, Simon M, Stintzing FC, Wink M. Front Pharmacol. 2022 Aug 24; 13:956541. doi: 10.3389/fphar.2022.956541. Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being.

Laskowska AK, Wilczak A, Skowrońska W, Michel P, Melzig MF, Czerwińska ME. Front Pharmacol. 2022 Sep 30; 13:981874. doi: 10.3389/fphar.2022.981874. Fruits of Hippophaë rhamnoides in human leukocytes and Caco-2 cell monolayer models-A question about their preventive role in lipopolysaccharide leakage and cytokine secretion in endotoxemia.



Bobowska A, Granica S, Filipek A, Melzig MF, Moeslinger T, Zentek J, Kruk A, Piwowarski JP. Eur J Nutr. 2021 Jun;60(4):1957-1972. doi: 10.1007/s00394-020-02386-y. Comparative studies of urolithins and their phase II metabolites on macrophage and neutrophil functions.

Granica S, Vahjen W, Zentek J, Melzig MF, Pawłowska KA, Piwowarski JP. J Nat Prod. 2020 Dec 24;83(12):3614-3622. doi: 10.1021/acs.jnatprod.0c00776. Lythrum salicaria Ellagitannins Stimulate IPEC-J2 Cells Monolayer Formation and Inhibit Enteropathogenic Escherichia coli Growth and Adhesion.

Popowski D, Czerwińska ME, Kruk A, Pawłowska KA, Zentek J, Melzig MF, Piwowarski JP, Granica S. J Ethnopharmacol. 2021 Jun 12; 273:113924. doi: 10.1016/j.jep.2021.113924. Gut microbiota metabolism and the permeability of natural products contained in infusions from herb of European goldenrod Solidago virgaurea L.

Popowski D, Pawłowska KA, Deipenbrock M, Hensel A, Kruk A, Melzig MF, Piwowarski JP, Granica S. J Ethnopharmacol. 2021 Jun 28; 274:114053. doi: 10.1016/j.jep.2021.114053. Antiadhesive activity of hydroethanolic extract from bean pods of Phaseolus vulgaris (common bean) against uropathogenic E. coli and permeability of its constituents through Caco-2 cells    monolayer.

Siegień J, Buchholz T, Popowski D, Granica S, Osińska E, Melzig MF, Czerwińska ME. Food Chem. 2021 Sep 1; 355:129414. doi: 10.1016/j.foodchem.2021.129414. Pancreatic lipase and α-amylase inhibitory activity of extracts from selected plant materials after gastrointestinal digestion in vitro.

Woith E, Guerriero G, Hausman JF, Renaut J, Leclercq CC, Weise C, Legay S, Weng A, Melzig MF. Int J Mol Sci. 2021 Apr 2;22(7):3719. doi: 10.3390/ijms22073719. Plant Extracellular Vesicles and Nanovesicles: Focus on Secondary Metabolites, Proteins and Lipids with Perspectives on Their Potential and Sources.

Fouedjou RT, Ponou BK, Teponno RB, Melzig M, Tanaka C, Miyamoto T, Tapondjou LA. Nat Prod Res. 2022 Oct;36(19):4949-4956. doi: 10.1080/14786419.2021.1914030. Two new triterpenoid saponins: telephiifoliosides A and B from the roots of Corrigiola litoralis subsp. telephiifolia (Pourr.) Briq.

Farinacci P, Mevissen M, Ayrle H, Maurer V, Sørensen Dalgaard T, Melzig MF, Walkenhorst M. Planta Med. 2022 Mar;88(3-04):200-217. doi: 10.1055/a-1543-5502. Medicinal Plants for Prophylaxis and Therapy of Common Infectious Diseases in Poultry- A Systematic Review of In Vivo Studies.

Schreck K, Melzig MF. Front Pharmacol. 2021 Aug 20; 12:692566. doi: 10.3389/fphar.2021.692566. Traditionally Used Plants in the Treatment of Diabetes Mellitus: Screening for Uptake Inhibition of Glucose and Fructose in the Caco2-Cell Model.

Czerwińska ME, Bobińska A, Cichocka K, Buchholz T, Woliński K, Melzig MF. Plants (Basel). 2021 Oct 30;10(11):2347. doi: 10.3390/plants10112347. Cornus mas and Cornus officinalis-A Comparison of Antioxidant and Immunomodulatory Activities of Standardized Fruit Extracts in Human Neutrophils and Caco-2 Models.



Truba J, Stanisławska I, Walasek M, Wieczorkowska W, Woliński K, Buchholz T, Melzig MF, Czerwińska ME. Plants (Basel). 9 (2020) pii: E122. Inhibition of Digestive Enzymes and Antioxidant Activity of Extracts from Fruits of Cornus albaCornus sanguinea subsp. hungarica and Cornus florida-A Comparative Study.

Melzig MF, Böttger S. Planta Med. 2020 Mar 10. doi: 10.1055/a-1129-7214. Tormentillae rhizoma - Review for an Underestimated European Herbal Drug.

Yu L, Hou Y, Xie W, Camacho JLC, Cheng C, Holle A, Young J, Trappmann B, Zhao W, Melzig MF, Cavalcanti-Adam EA, Zhao C, Spatz JP, Wei Q, Haag R. Adv Mater. 2020 Jul;32(29): e2002566. doi: 10.1002/adma.202002566. Ligand Diffusion Enables Force-Independent Cell Adhesion via Activating α5β1 Integrin and Initiating Rac and RhoA Signaling.

Dadi TH, Vahjen W, Zentek J, Melzig MF, Granica S, Piwowarski JP. J Ethnopharmacol. 2020 Oct 28; 261:113073. doi: 10.1016/j.jep.2020.113073. Lythrum salicaria L. herb and gut microbiota of healthy post-weaning piglets. Focus on prebiotic properties and formation of postbiotic metabolites in ex vivo cultures.

Weise C, Schrot A, Wuerger LTD, Adolf J, Gilabert-Oriol R, Sama S, Melzig MF, Weng A. Sci Rep. 2020 Sep 21;10(1):15377. doi: 10.1038/s41598-020-72282-2. An unusual type I ribosome-inactivating protein from Agrostemma githago L.



Świerczewska A, Buchholz T, Melzig MF, Czerwińska ME. J Food Drug Anal. 27 (2019) 249-258. In vitro α-amylase and pancreatic lipase inhibitory activity of Cornus mas L. and Cornus alba L. fruit extracts.

Guenther F, Maus D, Hedtrich S, Melzig MF. Planta Med. 85 (2019) 578-582. Serine Protease Mauritanicain from Euphorbia mauritanica and Phorbol-12-myristate-13-acetate Modulate theIL-8 Release in Fibroblasts and HaCaT Keratinocytes.

Woith E, Melzig MF. Int J Mol Sci. 20 (2019) pii: E357. Extracellular Vesicles from Fresh and Dried Plants-Simultaneous Purification and Visualization Using Gel Electrophoresis.

Sama S, Jerz G, Thakur M, Melzig MF, Weng A. Planta Med. 85 (2019) 513-518. Structure-Activity Relationship of Transfection-Modulating Saponins - A Pursuit for the Optimal Gene Trafficker.

Tresch M, Mevissen M, Ayrle H, Melzig M, Roosje P, Walkenhorst M. BMC Vet Res. 15 (2019) 174. Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review.

Bittner M, Schenk R, Springer A, Melzig MF. Planta Med. 85 (2019) 1160-1167.

Profiles of Phenolic Acids and Triterpene Glycosides in Commercial and Cultivated Black Cohosh.

Kayangar M, Ngansop Nono R, Kühlborn J, Tchuenguem R, Ponou BK, Jenett-Siems K, Teponno RB, Dzoyem JP, Opatz T, Melzig MF, Tapondjou LA. Z Naturforsch C J Biosci. 74 (2019) 289-293. A new ursane-type triterpene oxoglucopyranoside from Crossopteryx febrifuga.

Stephany-Brassesco I, Bereswill S, Heimesaat MM, Melzig MF. Eur J Microbiol Immunol (Bp). 9 (2019) 100-104. Synergistic Antimicrobial Effects of Cefabronchin®.

Woith E, Fuhrmann G, Melzig MF. Int J Mol Sci. 20 (2019) pii: E5695. Extracellular Vesicles-Connecting Kingdoms.



Sama S, Woith E, Walther W, Jerz G, Chen W, Hart S, Melzig MF, Weng A. J Control Release. 275 (2018) 208-216. Targeted suicide gene transfections reveal promising results in nu/nu mice with aggressive neuroblastoma.

Xie W, Melzig MF. Molecules. 23 (2018) pii: E919. The Stability of Medicinal Plant microRNAs in the Herb Preparation Process.

Hou Y, Xie W, Achazi K, Cuellar-Camacho JL, Melzig MF, Chen W, Haag R. Acta Biomater. 77 (2018) 28-37. Injectable degradable PVA microgels prepared by microfluidic technology for controlled osteogenic differentiation of mesenchymal stem cells.

Sama S, Jerz G, Schmieder P, Joseph JF, Melzig MF, Weng A. J Biotechnol. 284 (2018) 131-139. Plant derived triterpenes from Gypsophila elegans M.Bieb. enable non-toxic delivery of gene loaded nanoplexes.

Czerwińska ME, Melzig MF. Front Pharmacol. 9 (2018) 894. Cornus mas and Cornus officinalis-Analogies and Differences of Two Medicinal Plants Traditionally Used.

Schreck K, Melzig MF. Molecules. 23 (2018) pii: E2544. Intestinal Saturated Long-Chain Fatty Acid, Glucose and Fructose Transporters and Their Inhibition by Natural Plant Extracts in Caco-2 Cells. Correction in Molecules. 23 (2018) pii: E3290.



Flemmig M, Domsalla A, Rawel H, Melzig MF. Planta Med. 83 (2017) 551-556. Isolation and Characterization of Mauritanicain, a Serine Protease from the Latex of Euphorbia mauritanica L.

Tapondjou LA, Jenett-Siems K, Siems K, Weng A, Melzig MF. Nat Prod Commun. 12 (2017) 347-350. Flavonol Glycosides and Cytotoxic Steroidal Saponins from Furcraea tuberosa (Agavaceae).

Aierken A, Buchholz T, Chen C, Zhang X, Melzig MF. J Sci Food Agric. 97 (2017) 4557-4561. Hypoglycemic effect of hawthorn in type II diabetes mellitus rat model.

Bittner M, Krähmer A, Schenk R, Springer A, Gudi G, Melzig MF. Planta Med. 83 (2017) 1085-1096. NIR Spectroscopy of Actaea racemosa L. rhizome - En Route to Fast and Low-Cost Quality Assessment.

Tchegnitegni BT, Teponno RB, Jenett-Siems K, Melzig MF, Miyamoto T, Tapondjou LA. Z Naturforsch C. 72 (2017) 477-482. A dihydrochalcone derivative and further steroidal saponins from Sansevieria trifasciata Prain.

Bhargava C, Dürkop H, Zhao X, Weng A, Melzig MF, Fuchs H. Mol Oncol. 11 (2017) 1527-1543. Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861.

Sama S, Jerz G, Schmieder P, Woith E, Melzig MF, Weng A. Int J Pharm. 534 (2017) 195-205. Sapofectosid - Ensuring non-toxic and effective DNA and RNA delivery.

Xie W, Adolf J, Melzig MF. PLoS One. 12 (2017) e0187776. Identification of Viscum album L. miRNAs and prediction of their medicinal values.

Woith E, Stintzing F, Melzig MF. Pharmazie. 72 (2017) 490-496. SOD activity and extremophilicity: a screening of various plant species.


Dr. rer. nat Alexander Weng:


Schlaak L., Weise C., Kuropka B., Weng A. (2022) Sapovaccarin-S1 and -S2, Two Type I RIP Isoforms from the seeds of Saponaria vaccaria L., Toxins, 14 (7), 449.

Panjideh H., Niesler N., Weng A., Fuchs H. (2022) Improved therapy of B cell non-Hodgkin lymphoma by obinutuzumab-dianthin conjugates in combination with the endosomal escape enhancer SO1861, Toxins 14(7), 478.

Sonntag A., Mitdank H., Weng, A. (2022) Construction of Minicircle Suicide Genes Coding for Ribosome-Inactivating Proteins, Methods in Molecular Biology, Methods Mol Biol. 2521:157-171.

Mitdank, H., Tröger, M., Sonntag, A., Amini Shirazi, N., Woith, E., Fuchs, H., Kobelt, D., Walther, W., Weng, A. (2022) Suicide nanoplasmids coding for ribosome-inactivating proteins, Eur J Pharm Sci. 170, 106107.



Mitdank, H., Sama, S., Tröger, M., Testa, MF., Ferrarese, D., Balestra, D., Pinotti, M., Weng, A. (2021) An advanced method for the small-scale production of high quality minicircle-DNA, Int J Pharm. 605, 120830.

Woith, E., Guerriero, G., Hausman, JF., Renaut J., Leclercq, C., Weng, A., & Melzig, MF. (2021) Potential, properties and sources of plant derived extracellular vesicles and nanovesicles, Int J Mol Sci. 22(7), 3719.



Clochard, J., Jerz, G., Schmieder, P., Mitdank, H., Troger, M., Sama, S. & Weng, A. (2020) A new acetylated triterpene saponin from Agrostemma githago L. modulates gene delivery efficiently and shows a high cellular tolerance, Int J Pharm. 589, 119822.

Weise, C., Schrot, A., Wuerger, L. T. D., Adolf, J., Gilabert-Oriol, R., Sama, S., Melzig, M. F. & Weng, A. (2020) An unusual type I ribosome-inactivating protein from Agrostemma githago L, Sci Rep. 10, 15377.


Kokorin, A., Weise, C., Sama, S., Weng, A. (2019) A new type 1 ribosome-inactivating protein from the seeds of Gypsophila elegans M.Bieb. Phytochemistry. 157:121-127.

Sama S., Jerz G., Thakur M., Melzig MF. & Weng A. (2019) Structure-Activity Relationship of Transfection-Modulating Saponins - A Pursuit for the Optimal Gene Trafficker. Planta Med. (Epub ahead of print, doi: 10.1055/a-0863-4795)


Sama, S., Jerz G., Schmieder, P., Joseph, JF., Melzig, MF., Weng, A. (2018) Plant derived triterpenes from Gypsophila elegans M.Bieb. enable non-toxic delivery of gene loaded nanoplexes. J Biotechnol. 284:131-139.

Sama, S., Woith, E., Walther, W., Jerz, G., Chen, W., Hart, S., Melzig, MF., Weng, A. (2018) Targeted suicide gene transfections reveal promising results in nu/nu mice with aggressive neuroblastoma, Journal of controlled release, accepted manuscript.

Weng, A. (2017) A novel adenine-releasing assay for ribosome-inactivating proteins. J Chromatogr B Analyt Technol Biomed Life Sci. 1072:300-304.


Sama, S., Jerz, G., Schmieder, P., Woith, E., Melzig, MF., Weng, A. (2017) Sapofectosid - Ensuring non-toxic and effective DNA and RNA delivery. Int J Pharm. 534(1-2):195-205.

Bhargava, C., Dürkop, H., Zhao, X., Weng, A., Melzig MF., Fuchs, H. (2017) Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861. Mol Oncol. 11(11):1527-1543.

Fuchs, H., Niesler, N., Trautner, A., Sama, S., Jerz, G., Panjideh, H., Weng, A. (2017) Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies. Biomedicines. 29;5(2).

Gilabert-Oriol, R., Furness, SGB., Stringer, BW., Weng, A., Fuchs, H., Day, BW., Kourakis, A., Boyd, AW., Hare, DL., Thakur, M., Johns, TG., Wookey, PJ. (2017) Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma. Cancer Immunol Immunother. 66(9):1217-1228.



Gilabert-Oriol, R., Thakur, M., Haussmann, K., Niesler, N., Bhargava, C., Gorick, C., Fuchs, H. & Weng, A. (2016) Saponins from Saponaria officinalis L. Augment the Efficacy of a Rituximab-Immunotoxin, Planta medica82(18), 1525-1531.

Fuchs, H., Weng, A. & Gilabert-Oriol, R. (2016) Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers, Toxins. 8(7).

Xie, W., Weng, A. & Melzig, M. F. (2016) MicroRNAs as New Bioactive Components in Medicinal Plants, Planta medica82(13), 1153-1162.



Weng, A., Manunta, M. D., Thakur, M., Gilabert-Oriol, R., Tagalakis, A. D., Eddaoudi, A., Munye, M. M., Vink, C. A., Wiesner, B., Eichhorst, J., Melzig, M. F. & Hart, S. L. (2015) Improved intracellular delivery of peptide- and lipid-nanoplexes by natural glycosides, Journal of controlled release : official journal of the Controlled Release Society. 206, 75-90.

Schrot, J., Weng, A. & Melzig, M. F. (2015) Ribosome-inactivating and related proteins, Toxins. 7, 1556-615.

Holmes, S. E., Bachran, C., Fuchs, H., Weng, A., Melzig, M. F., Flavell, S. U. & Flavell, D. J. (2015) Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent, Immunopharmacology and immunotoxicology. 37, 42-55.

Gilabert-Oriol, R., Weng, A., von Mallinckrodt, B., Stoshel, A., Nissi, L., Melzig, M. F., Fuchs, H. & Thakur, M. (2015) Electrophoretic mobility as a tool to separate immune adjuvant saponins from Quillaja saponaria Molina, International journal of pharmaceutics. 487, 39-48.

Gilabert-Oriol, R., Weng, A., Trautner, A., Weise, C., Schmid, D., Bhargava, C., Niesler, N., Wookey, P. J., Fuchs, H. & Thakur, M. (2015) Combinatorial approach to increase efficacy of Cetuximab, Panitumumab and Trastuzumab by dianthin conjugation and co-application of SO1861, Biochemical pharmacology. 97, 247-55.



von Mallinckrodt, B., Thakur, M., Weng, A., Gilabert-Oriol, R., Durkop, H., Brenner, W., Lukas, M., Beindorff, N., Melzig, M. F. & Fuchs, H. (2014) Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma, Future oncology. 10, 2161-75.

Thakur, M., Jerz, G., Tuwalska, D., Gilabert-Oriol, R., Wybraniec, S., Winterhalter, P., Fuchs, H. & Weng, A. (2014) High-speed countercurrent chromatographic recovery and off-line electrospray ionization mass spectrometry profiling of bisdesmodic saponins from Saponaria officinalis possessing synergistic toxicity enhancing properties on targeted antitumor toxins, Journal of chromatography B, Analytical technologies in the biomedical and life sciences. 955-956, 1-9.

Gilabert-Oriol, R., Weng, A., Mallinckrodt, B., Melzig, M. F., Fuchs, H. & Thakur, M. (2014) Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy, Current pharmaceutical design. 20, 6584-643.

Gilabert-Oriol, R., Thakur, M., von Mallinckrodt, B., Bhargava, C., Wiesner, B., Eichhorst, J., Melzig, M. F., Fuchs, H. & Weng, A. (2014) Reporter assay for endo/lysosomal escape of toxin-based therapeutics, Toxins. 6, 1644-66.



Thakur, M., Weng, A., Pieper, A., Mergel, K., von Mallinckrodt, B., Gilabert-Oriol, R., Gorick, C., Wiesner, B., Eichhorst, J., Melzig, M. F. & Fuchs, H. (2013) Macromolecular interactions of triterpenoids and targeted toxins: role of saponins charge, International journal of biological macromolecules. 61, 285-94.

Thakur, M., Mergel, K., Weng, A., von Mallinckrodt, B., Gilabert-Oriol, R., Durkop, H., Melzig, M. F. & Fuchs, H. (2013) Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: an evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice, Molecular oncology. 7, 475-83.

Gilabert-Oriol, R., Thakur, M., Weise, C., Dernedde, J., von Mallinckrodt, B., Fuchs, H. & Weng, A. (2013) Small structural differences of targeted anti-tumor toxins result in strong variation of protein expression, Protein expression and purification. 91, 54-60.

Gilabert-Oriol, R., Thakur, M., von Mallinckrodt, B., Hug, T., Wiesner, B., Eichhorst, J., Melzig, M. F., Fuchs, H. & Weng, A. (2013) Modified trastuzumab and cetuximab mediate efficient toxin delivery while retaining antibody-dependent cell-mediated cytotoxicity in target cells, Molecular pharmaceutics. 10, 4347-57.

15. Gilabert-Oriol, R., Mergel, K., Thakur, M., von Mallinckrodt, B., Melzig, M. F., Fuchs, H. & Weng, A. (2013) Real-time analysis of membrane permeabilizing effects of oleanane saponins, Bioorganic & medicinal chemistry. 21, 2387-95.



16. Weng, A., Thakur, M., von Mallinckrodt, B., Beceren-Braun, F., Gilabert-Oriol, R., Wiesner, B., Eichhorst, J., Bottger, S., Melzig, M. F. & Fuchs, H. (2012) Saponins modulate the intracellular trafficking of protein toxins, Journal of controlled release : official journal of the Controlled Release Society. 164, 74-86.

Weng, A., Thakur, M., Beceren-Braun, F., Bachran, D., Bachran, C., Riese, S. B., Jenett-Siems, K., Gilabert-Oriol, R., Melzig, M. F. & Fuchs, H. (2012) The toxin component of targeted anti-tumor toxins determines their efficacy increase by saponins, Molecular oncology. 6, 323-32.

Thakur, M., Mergel, K., Weng, A., Frech, S., Gilabert-Oriol, R., Bachran, D., Melzig, M. F. & Fuchs, H. (2012) Real time monitoring of the cell viability during treatment with tumor-targeted toxins and saponins using impedance measurement, Biosensors & bioelectronics. 35, 503-6.

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