Apothekerin Kristina Puls
Institute of Pharmacy (Wolber lab)
Pharmaceutical and Medicinal Chemistry
Molecular Design Lab
Design of new modulators of the kappa opioid receptor
My research focusses on the kappa opioid receptor (KOR). The KOR belongs to the wide family of G protein coupled receptors (GPCRs), that represent important drug targets. I believe that the development of new KOR modulators could lead to safer analgesics for severe pain treatment. Particular I want to achieve a better understanding of the activation mechanism and downstream signaling pathways of the KOR and design new KOR modulators that are G protein biased, i.e. they activate G proteins rather than arrestins. For that approach I use in silico drug design methods with subsequent pharmacological validation.