Welcome to the Lauster Group.

The Lauster Lab is an interdisciplinary research group working at the interface of biopharmaceuticals, chemical biology, and biophysics, with a strong focus on translating molecular discoveries into therapeutic concepts. We combine fundamental mechanistic studies with applied research to develop bioactive molecules for respiratory medicine.

Our work centers on the design of biomimetic peptides inspired by viral receptors, antibodies, and lung mucins, created through rational engineering, computational approaches, and high-throughput screening. These peptides serve as antiviral decoys, mucolytic agents, and precision components for targeted nanotherapeutics. In parallel, we investigate protein self-assembly and redox-dependent structural changes, and we develop molecular sensing tools for biothiols to better understand redox processes in mucus and other biological matrices.

To study structure-function relationships, we apply a broad spectrum of quantitative biophysical techniques, including microscale thermophoresis (MST), interferometric scattering microscopy (mass photometry), advanced fluorescence microscopy, and cone-and-plate rheology. This integrated methodology allows us to quantify molecular interactions and material properties across multiple scales.

Our long-term goal is the development of inhalable peptide–nanoparticle conjugates for site-specific delivery in the lung. By combining molecular design with a detailed understanding of mucus biology and respiratory barriers, we aim to contribute to new therapeutic strategies for viral infections, mucus-associated diseases, and conditions involving impaired mucosal defense.

Image Credit: Cosmin St. Butnarasu