A butterfly effect: From a single nucleotide to altered immunity
Bechtella, L., Pagel, K.* – 2023
Proteoforms show subtle differences that are difficult to detect.
Generated by single-nucleotide polymorphism or post-translational
modifications, they are challenging to analyze and difficult to design
for therapeutic applications. In this issue of Chem, Robinson and co-
workers present a systematic native mass spectrometry (MS) study
in which the fine modulations of SERPIN proteoforms are linked to