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Gas-phase infrared spectroscopy of glycans and glycoconjugates

Greis, K; Kirschbaum, C.; von Helden, G.; Pagel K.* – 2022

Glycans are intrinsically complex biomolecules that pose particular analytical challenges. Standard workflows for glycan analysis are based on mass spectrometry, often coupled with separation techniques such as liquid chromatography and ion mobility spectrometry. However, this approach does not yield direct structural information and cannot always distinguish between isomers. This gap might be filled in the future by gas-phase infrared spectroscopy, which has emerged as a promising structure-sensitive technique for glycan fingerprinting. This review highlights recent applications of gas-phase infrared spectroscopy for the analysis of synthetic and biological glycans and how they can be integrated into mass spectrometry-based workflows.

Title
Gas-phase infrared spectroscopy of glycans and glycoconjugates
Author
Greis, K; Kirschbaum, C.; von Helden, G.; Pagel K.*
Date
2022-02
Source(s)
Citation
Curr. Opin. Struct. Biol. 2022, https://doi.org/10.1016/j.sbi.2021.11.006
Type
Text
masses4masses
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