Springe direkt zu Inhalt

The Impact of Leaving Group Anomericity on the Structure of Glycosyl Cations

GlycoCat

Glyco-Cation

Greis, K.; Much, E.; Thomas, D. A.; Kirschbaum, C.; Lettow, M.; Moon, S.; Pardo, A.; von Helden, G.; Meijer, G.; Gilmore, K.; Seeberger, P. H.; Pagel, K.;* – 2020

It has been reported that fragments produced by glycosidic bond breakage in mass spectrometry‐based experiments can retain a memory of their anomeric configuration, which has major implications for glycan sequencing. Here we use cryogenic vibrational spectroscopy and ion mobility‐mass spectrometry to study the structure of B‐type fragments of protected galactosides. Cationic fragments were generated from glycosyl donors carrying trichloroacetimidate or thioethyl leaving groups of different anomeric configuration. The obtained infrared signatures indicate that the investigated fragments exhibit an identical structure, which suggests that there is no anomeric memory in B‐type ions of fully protected monosaccharides.

Title
The Impact of Leaving Group Anomericity on the Structure of Glycosyl Cations
Author
Greis, K.; Much, E.; Thomas, D. A.; Kirschbaum, C.; Lettow, M.; Moon, S.; Pardo, A.; von Helden, G.; Meijer, G.; Gilmore, K.; Seeberger, P. H.; Pagel, K.;*
Date
2020
Source(s)
Citation
ChemPhysChem 2020, 21 (17) 1905-1907.
Type
Text
masses4masses
v01
v02
twitter