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Advancing Solutions to the Carbohydrate Sequencing Challenge

TOC_Gray_JACS_pub_082

TOC

Gray, C.J.; Migas, L.G.; Barran, P.E.; Pagel, K.; Seeberger, P.H.; Eyers, C.E.; Boons, G.-J.; Pohl, N.L.B.; Compagnon, I.; Widmalm, G.; Flitsch, S.L. – 2019

Carbohydrates possess a variety of distinct features with stereochemistry playing a particularly important role in distinguishing their structure and function. Monosaccharide building blocks are defined by a high density of chiral centers. Additionally, the anomericity and regio-chemistry of the glycosidic linkages carry important biological information. Any carbohydrate-sequencing method needs to be precise in determining all aspects of this stereo-diversity. Recently, several advances have been made in developing fast and precise analytical techniques that have the potential to address the stereochemical complexity of carbohydrates. This perspective seeks to provide an overview of some of these emerging techniques, focusing on those that are based on NMR and MS-hybridized technologies including ion mobility spectrometry and IR spectroscopy.

Title
Advancing Solutions to the Carbohydrate Sequencing Challenge
Author
Gray, C.J.; Migas, L.G.; Barran, P.E.; Pagel, K.; Seeberger, P.H.; Eyers, C.E.; Boons, G.-J.; Pohl, N.L.B.; Compagnon, I.; Widmalm, G.; Flitsch, S.L.
Date
2019
Identifier
10.1021/jacs.9b06406
Source(s)
Citation
J. Am. Chem. Soc. 2019, 141, 14463–14479.
Type
Text
masses4masses
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