From α-helix to β-sheet - A reversible metal ion induced peptide secondary structure switch
Pagel, K.; Vagt, T.; Kohajda, T.; Koksch, B. – 2005
Here we introduce a peptide model based on an α-helical coiled coil peptide, providing a simple system which can be used for a systematic study of the impact of different metal ions in different oxidation states on peptide secondary structure on a molecular level; histidine residues were incorporated into the heptad repeat to generate possible complexation sites for Cu2+ and Zn2+ ions.
Highlighted in: Switching off neurodegenerative diseases, Chemistry World 2005, 2(8).