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From α-helix to β-sheet - A reversible metal ion induced peptide secondary structure switch

Pagel, K.; Vagt, T.; Kohajda, T.; Koksch, B. – 2005

Here we introduce a peptide model based on an α-helical coiled coil peptide, providing a simple system which can be used for a systematic study of the impact of different metal ions in different oxidation states on peptide secondary structure on a molecular level; histidine residues were incorporated into the heptad repeat to generate possible complexation sites for Cu2+ and Zn2+ ions.

Title
From α-helix to β-sheet - A reversible metal ion induced peptide secondary structure switch
Author
Pagel, K.; Vagt, T.; Kohajda, T.; Koksch, B.
Date
2005
Identifier
10.1039/B505979H
Source(s)
Citation
Org. Biomol. Chem. 2005, 3, 2500-2502
Type
Text

Highlighted in: Switching off neurodegenerative diseases, Chemistry World 2005, 2(8).

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