The Impact of Halogenated Phenylalanine Derivatives on NFGAIL Amyloid Formation (VIP Paper, Cover Image)
S. Chowdhary, J. Moschner, D. J. Mikolajczak, M. Becker, A. F. Thünemann, C. Kästner, D. Klemczak, A.-K. Stegemann, C. Böttcher, P. Metrangolo, R. R. Netz, B. Koksch – 2020
Abstract: As shown for the model peptide NFGAIL, the intro-duction of different fluorinated phenylalanine derivatives leads to specific amyloid-folding kinetics through an alteration in hydro-phobicity and changes in their α-frameworks. This is represen-ted by the clock, as its hand (the “F” for fluorine) determines the self-assembly process. The extent of fluorination, illustrated as potential plots, acts as a dimension of change not only for aggregation kinetics, but also for the morphology of resulting fibrils, as revealed by TEM micrographs. More information can be found in the full paper by B. Koksch et al. The picture was created by S.C., Helmut Fouquet, J.M., M.B., R.R.N. and B.K.