Total synthesis has changed our world profoundly by widely advancing the fields of chemistry, biology and medicine. To ensure future progress, we must explore and exploit reactivity beyond classical patterns. By finding ways to manipulate the aliphatic carbon backbone of molecules, syntheses will become possible that can provide supplies of bioactive natural products and designed analogs expediently, efficiently and economically.

Technology-driven synthesis is an important part of our work. We design and build novel reactors to enable and facilitate synthetic operations for environmentally and economically more sustainable approaches towards complex molecular entities.