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Enantioselective Dichlorination of Allylic Alcohols

K.C. Nicolaou, N.L. Simmons, Y. Ying, P. Heretsch, J.S. Chen – 2011

The development of an enantioselective allylic alcohol dichlorination catalyzed by dimeric cinchona alkaloid derivatives and employing aryl iododichlorides as chlorine sources is reported. Reaction optimization, exploration of the substrate scope, and a model for stereoinduction are presented.

Title
Enantioselective Dichlorination of Allylic Alcohols
Author
K.C. Nicolaou, N.L. Simmons, Y. Ying, P. Heretsch, J.S. Chen
Date
2011
Identifier
DOI: 10.1021/ja202555m
Citation
J. Am. Chem. Soc. 2011, 133 8134-8137