Exo-Cyclopamine–a stable and potent inhibitor of hedgehog-signaling
P. Heretsch, A. Büttner, L. Tzagkaroulaki, S. Zahn, B. Kirchner, A. Giannis – 2011
The combination of theoretical and computational studies with organic synthesis and biological investigations has led to exo-cyclopamine. This stable and highly potent derivative of cyclopamine promises big potential as an experimental drug against several types of human cancer.
Title
Exo-Cyclopamine–a stable and potent inhibitor of hedgehog-signaling
Author
P. Heretsch, A. Büttner, L. Tzagkaroulaki, S. Zahn, B. Kirchner, A. Giannis
Date
2011
Identifier
DOI: 10.1039/C1CC11782C
Citation
Chem. Commun. 2011, 47, 7362-7364