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Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

F.L. Duecker, F. Reuß, P. Heretsch – 2019

Classical steroids are long-known privileged leads in drug discovery. Their rearranged counterparts, though, have so far received less attention, although recent isolation and biological testing programmes have revealed a plethora of molecular entities that are both structurally intriguing, as well as biologically relevant. This review will highlight those natural products, and focus on ergostane-derived abeo-steroids. Their isolation, structure elucidation, and biological properties are reported. A special emphasis of this review lies in their respective (and typically proposed) biosyntheses, to help guide future bio-inspired synthetic attempts.

Title
Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects
Author
F.L. Duecker, F. Reuß, P. Heretsch
Date
2019-01
Identifier
DOI: 10.1039/c8ob02325e
Citation
Org. Biomol. Chem. 2019, 17, 1624-1633.