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General Synthetic Approach to Functionalized Dihydrooxepines

K.C. Nicolaou, R. Yu, L. Shi, Q. Cai, M. Lu, P. Heretsch – 2013

A three-step sequence to access functionalized 4,5-dihydrooxepines from cyclohexenones has been developed. This approach features a regioselective Baeyer–Villiger oxidation and subsequent functionalization via the corresponding enol phosphate intermediate.

Title
General Synthetic Approach to Functionalized Dihydrooxepines
Author
K.C. Nicolaou, R. Yu, L. Shi, Q. Cai, M. Lu, P. Heretsch
Date
2013
Identifier
DOI: 10.1021/ol4006689
Citation
Org. Lett. 2013, 15, 1994-1997.