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Method Development

Our approach to method development is best described as problem-driven. In this regard, we aim to identify new transformations that shortcut synthetic sequences to substructures within our targeted molecules. In particular, we have been interested in the use of organocatalytic reactions in total synthesis. Organocatalysis has emerged as an efficient solution for the rapid and stereoselective synthesis of chiral chemical entities. In a mechanistically motivated program, we have been investigating reactivity of electron-rich dienamines as intermediates in catalysis.