86. Electrosynthesis of Protected Dehydroamino Acids
M. Gausmann, N. Kreidt, M. Christmann
A NaCl-mediated electrochemical oxidation of amino acid carbamates (R1 = Boc, Cbz) afforded α-methoxylated α-amino acids. Subsequent acid-catalyzed elimination delivered valuable dehydroamino acid derivatives. The simplicity of our setup using graphite-electrodes was showcased, producing N-Boc-ΔAla-OMe on a decagram scale.
Title
86. Electrosynthesis of Protected Dehydroamino Acids
Author
M. Gausmann, N. Kreidt, M. Christmann
Identifier
DOI: 10.1021/acs.orglett.3c00403
Citation
Org. Lett. 2023, 25, 2228-2232.