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84. Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis

S. Leisering, A. Mavroskoufis, P. Voßnacker, R. Zimmer, M. Christmann

A protecting-group-free synthesis of two endoperoxide natural products, plakortolide E and plakortolide I, is reported. Key steps are a vanadium-mediated epoxidation, an iron-catalyzed allylic substitution, and a cobalt-induced endoperoxide formation. Our approach combines chemoselective bond-forming reactions and one-pot operations to forge an overall efficient synthesis.

Title
84. Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis
Author
S. Leisering, A. Mavroskoufis, P. Voßnacker, R. Zimmer, M. Christmann
Identifier
DOI: 10.1021/acs.orglett.1c01457
Citation
Org. Lett. 2021, 23, 4731-4735.