84. Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis
S. Leisering, A. Mavroskoufis, P. Voßnacker, R. Zimmer, M. Christmann
A protecting-group-free synthesis of two endoperoxide natural products, plakortolide E and plakortolide I, is reported. Key steps are a vanadium-mediated epoxidation, an iron-catalyzed allylic substitution, and a cobalt-induced endoperoxide formation. Our approach combines chemoselective bond-forming reactions and one-pot operations to forge an overall efficient synthesis.