75. Synthesis of spongidine A, D and petrosaspongiolide L methyl ester using pyridine C-H functionalization
F. Bartels, M. Weber, M. Christmann
An efficient strategy for the synthesis of the potent phospholipase A2 inhibitors spongidine A and D is presented. The tetracyclic core of the natural products was assembled via an intramolecular hydrogen atom transfer‐initiated Minisci reaction. A divergent late‐stage functionalization of the tetracyclic ring system was also used to achieve a concise synthesis of petrosaspongiolide L methyl ester.