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75. Synthesis of spongidine A, D and petrosaspongiolide L methyl ester using pyridine C-H functionalization

F. Bartels, M. Weber, M. Christmann

An efficient strategy for the synthesis of the potent phospholipase A2 inhibitors spongidine A and D is presented. The tetracyclic core of the natural products was assembled via an intramolecular hydrogen atom transfer‐initiated Minisci reaction. A divergent late‐stage functionalization of the tetracyclic ring system was also used to achieve a concise synthesis of petrosaspongiolide L methyl ester.

Title
75. Synthesis of spongidine A, D and petrosaspongiolide L methyl ester using pyridine C-H functionalization
Author
F. Bartels, M. Weber, M. Christmann
Identifier
DOI: 10.1021/acs.orglett.9b04315
Citation
Org. Lett 2020, 22, 552–555