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73. Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal

C. Apel, M.‐A. Kasper, C. Stieger, C. P. R. Hackenberger, M. Christmann

A new lysine-reactive cyclopropropyl aldehyde for the covalent modification of proteins was developed. The reagent exploits a divinylcyclopropane–cycloheptadiene rearrangement to render the initial condensation irreversible. A labeling study on eGFP demonstrated excellent chemoselectivity for the modification of amine-nucleophiles with the possibility of subsequent modifications.

Title
73. Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal
Author
C. Apel, M.‐A. Kasper, C. Stieger, C. P. R. Hackenberger, M. Christmann
Identifier
DOI: 10.1021/acs.orglett.9b03982
Citation
Org. Lett 2019, 21, 10043–10047.