7. Rapid Access to Polyketide Scaffolds via Vinylogous Mukaiyama Aldol Reactions
J. Hassfeld, M. Christmann, M. Kalesse
The use of the Z-configured vinylogous silyl ketene acetals in Mukaiyama aldol reactions is described. Isopropyl alcohol as scavanger and the use of tris(pentafluorophenyl)borane as the Lewis acid are required for obtaining the γ-alkylated syn-product selectively. In cases of α-chiral aldehydes, Felkin−Anh selectivity was observed.