44. Enantiogroup-differentiating biocatalytic reductions of prochiral Cs-symmetrical dicarbonyl compounds to meso compounds
M. Skoupi, C. Vaxelaire, C. Strohmann, M. Christmann, C. M. Niemeyer
The stereoselective reduction of symmetrical prochiral dicarbonyl compounds bearing enantiotopic carbonyl groups yields several stereogenic centers in one step. In a proof-of-concept study, a new approach is described for the enzymatic desymmetrization of 5-nitrononane-2,8-dione via sequential biocatalytic reduction steps utilizing ketoreductases to yield all possible diastereomers of 5-nitrononane-2,8-diol.