40. Catalytic and Stereoselective ortho-Lithiation of a Ferrocene Derivative

P. Steffen, C. Unkelbach, M. Christmann, W. Hiller, C. Strohmann

N,N-Dimethylferrocenylmethylamine can be lithiated stereoselectively by iPrLi in pentane/Et2O using catalytic amounts of the chiral auxiliary (R,R)-TMCDA. In homogenous reactions, high e.r. values were obtained upon crystallization of the lithiated species. The catalytic activity of TMCDA is made possible by its release from the stereomerically pure lithioferrocene as it dimerizes to a homochiral dimeric etherate.

Title
40. Catalytic and Stereoselective ortho-Lithiation of a Ferrocene Derivative
Author
P. Steffen, C. Unkelbach, M. Christmann, W. Hiller, C. Strohmann
Identifier
DOI: 10.1002/anie.201303650
Citation
Angew. Chem. Int. Ed. 2013, 52, 9836–9840.