36. Enantioselective Tandem Reactions at Elevated Temperatures: One-Pot Hydroformylation/SN1 Alkylation
J. Stiller, A. J. Vorholt, K. A. Ostrowski, A. Behr, M. Christmann
Canned heat: The optimization of a tandem sequence of a metal-catalyzed and a subsequent organocatalytic reaction is described (see figure). The tandem sequence was initially optimized toward a high yield by variations of substrate ratio, rhodium precursor, and ligands. The tandem reaction is also extendable to more complex alkenes and to substrates with additional functional groups.