30. Transforming Terpene Feedstock into Polyketide Architecture
P. Winter, C. Vaxelaire, C. Heinz, M. Christmann
The Cu-catalyzed synthesis of skipped 1,4-dienes from allylic acetates and vinyl-Grignard reagents is key to bidirectional modifications of acyclic terpene acetates. As a result, trisubstituted double bond containing subunits can be readily transferred into complex polyketides from inexpensive bulk terpenes.