25. Total synthesis: Towards artificial terpene cyclases
M. Willot, M. Christmann
The plant-derived sesquiterpene englerin A is a potent inhibitor of several renal cancer cell lines. Two recent total syntheses have utilized cationic gold(I)-complexes to coax readily available open-chain precursors into englerin's challenging oxotricyclic core with enzyme-like precision.
Title
25. Total synthesis: Towards artificial terpene cyclases
Author
M. Willot, M. Christmann
Identifier
DOI: 10.1038/nchem.715
Source(s)
Citation
Nature Chem. 2010, 2, 519–520.