2. Total Synthesis of (+)-Ratjadone
M. Christmann, U. Bhatt, M. Quitschalle, E. Claus, M. Kalesse
The coupling of three fragments by a Wittig olefination and a subsequent selective Heck reaction are the pivotal steps in the the first total synthesis of ratjadone (see picture), a cytotoxic as well as antibiotically effective polyketide. This synthesis enabled the elucidation of the absolute configuration of the natural product. In this way it should also be possible to synthesize structural analogues with which the various cellular processes mediated by ratjadone can be studied.