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18. Synthesis of 4-Maleimidobutyric Acid and Related Maleimides

R. M. de Figueiredo, P. Oczipka, M. Christmann

Maleimidoalkanoic acids and their activated derivatives, such as their N-hydroxysuccinimide esters, are important, though expensive, linkers for the conjugation of biomolecules. During our synthesis of UCS1025A, we have developed a chromatography-free preparation of 4-maleimidobutyric acid on a one-mole scale.

Title
18. Synthesis of 4-Maleimidobutyric Acid and Related Maleimides
Author
R. M. de Figueiredo, P. Oczipka, M. Christmann
Identifier
DOI: 10.1055/s-2008-1032016
Source(s)
Citation
Synthesis 2008, 1316–1318.