18. Synthesis of 4-Maleimidobutyric Acid and Related Maleimides
R. M. de Figueiredo, P. Oczipka, M. Christmann
Maleimidoalkanoic acids and their activated derivatives, such as their N-hydroxysuccinimide esters, are important, though expensive, linkers for the conjugation of biomolecules. During our synthesis of UCS1025A, we have developed a chromatography-free preparation of 4-maleimidobutyric acid on a one-mole scale.