A Selection of Recent Publications

 Vallecillo-García P, Kühnlein MN, Orgeur M, Hansmeier NR, Kotsaris G, Meisen Z, Timmermann B, Giesecke-Thiel C, Hägerling R, Stricker S. Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation. Development 2024, 151 (17): dev202747. DOI: 10.1242/dev.202747

 Ugorets V, Mendez PL, Zagrebin D, Russo G, Kerkhoff Y, Kotsaris G, Jatzlau J, Stricker S, Knaus P. Dynamic remodeling of septin structures fine-tunes myogenic differentiation. iScience 2024, 27(9), 110630. DOI: 10.1016/j.isci.2024.110630

 Wei X, Rigopoulos A, Lienhard M, Pöhle-Kronawitter S, Kotsaris G, Franke G, Berndt N, Mejedo JO, Wu H, Börno S, Timmermann B, Murgai A, Glauben R, Stricker S. Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors. Nat. Commun. 2024, 15(1393). DOI: 10.1038/s41467-024-45618-z

 Vallecillo-García P, Orgeur M, Comai G, Poehle-Kronnawitter S, Fischer C, Gloger M, Dumas CE, Giesecke-Thiel C, Sauer S, Tajbakhsh S, Höpken UE, Stricker S. A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation. Immunity 2023, May 2:S1074-7613(23)00182-6.DOI:10.1016/j.immuni.2023.04.014

 Kotsaris G, Qazi TH, Bucher CH, Zahid H, Pöhle-Kronawitter S, Ugorets V, Jarassier W, Börno S, Timmermann B, Giesecke-Thiel C, Economides AN, Le Grand F, Vallecillo-García P, Knaus P, Geissler S, Stricker S. Odd skipped-related 1 controls the pro-regenerative response of Fibro-Adipogenic Progenitors. NPJ Regenerative Medicine 2023 8(19). DOI: 10.1038/s41536-023-00291-6

 Biferali B, Bianconi V, Perez DF, Pöhle-Kronawitter S, Marullo F, Maggio R, Santini T, Polverino F, Biagioni S, Summa V, Toniatti C, Pasini D, Stricker S, Di Fabio R, Chiacchiera F, Peruzzi G, Mozzetta C. Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair. Sci Adv. 2021; 7(23):eabd9371. DOI: 10.1126/sciadv.abd9371

 Comai GE, Tesařová M, Dupé V, Rhinn M, Vallecillo-García P, da Silva F, Feret B, Exelby K, Dollé P, Carlsson L, Pryce B, Spitz F, Stricker S, Zikmund T, Kaiser J, Briscoe J, Schedl A, Ghyselinck NB, Schweitzer R, Tajbakhsh S. Local retinoic acid signaling directs emergence of the extraocular muscle functional unit. PLoS Biol. 2020; Nov 17; 18(11):e3000902. DOI: 10.1371/journal.pbio.3000902

 Wei X, Franke J, Ost M, Wardelmann K, Börno S, Timmermann B, Meierhofer D, Kleinridders A, Klaus S, Stricker S. Cell autonomous requirement of Neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis. Journal of Cachexia, Sarcopenia and Muscle, 2020; 11, 1758-1778 DOI: 10.1002/jcsm.12632

 Feng C, Chan WCW, Lam Y, Wang X, Chen P, Niu B, Ng VCW, Yeo JC, Stricker S, Cheah KSE, Koch M, Mundlos S, Ng HH, Chan D. Lgr5 and Col22a1 Mark Progenitor Cells in the Lineage toward Juvenile Articular Chondrocytes. Stem Cell Rep. 2019; 13(4), 713-29 DOI: 10.1016/j.stemcr.2019.08.006

 Stumm J, Vallecilo-Garcia P, vom Hofe-Schneider S, Ollitrault D, Schrewe H, Economides AN, Marazzi G, Sassoon D, Stricker S. Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury. Stem Cell Res. 2018; 32, 8-16 DOI: 10.1016/j.scr.2018.08.010

 Murgai A, Altmeyer S, Wiegand S, Tylzanowski P, Stricker S. Cooperation of BMP and IHH signaling in interdigital cell fate determination. PLoS ONE 2018; 13(5), e0197535. DOI: 10.1371/journal.pone.0197535

 Orgeur M, Martens M, Leonte G, Nassari S, Bonnin MA, Börno ST, Timmermann B, Hecht J, Duprez D, Stricker S. Genome-wide strategies identify downstream target genes of connective tissue-associated transcription factors. Development 2018; 145, dev161208 DOI: 10.1242/dev.161208

 Orgeur M, Martens M, Börno ST, Timmermann B, Duprez D, Stricker S. A dual transcript-discovery approach to improve the delimitation of gene features from RNA-seq data in the chicken model. Biol. Open 2018; 7, bio028498 DOI: 10.1242/bio.028498

 Nassari S, Blavet S, Bonnin M-A, Stricker S, Duprez D, Fournier-Thibault C. The chemokines CXCL12 and CXCL14 differentially regulate connective tissue markers during limb development. Sci. Rep. 2017; 7(1), 17279. DOI: 10.1038/s41598-017-17490-z

 Vallecillo García P, Orgeur M, Vom Hofe-Schneider S, Stumm J, Kappert V, Ibrahim DM, Börno ST, Hayashi S, Relaix F, Hildebrandt K, Sengle G, Koch M, Timmermann B, Marazzi G, Sassoon DA, Duprez D, Stricker S. Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development. Nat. Commun. 2017; 8:1218.DOI: 10.1038/s41467-017-01120-3

Dörpholz G, Murgai A, Jatzlau J, Horbelt D, Belverdi MP, Heroven C, Schreiber I, Wendel G, Ruschke K, Stricker S, Knaus P. IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation. Sci. Rep.2017; 7(1), 8778. DOI: 10.1038/s41598-017-08676-6

Bernatik O, Radaskiewicz T, Behal M, Dave Z, Witte F, Mahl A, Cernohorsky NH, Krejci P, Stricker S, Bryja V. A novel role for the BMP antagonist Noggin in sensitizing cells to non-canonical Wnt-5a/Ror2/Dishevelled pathway activation. Front. Cell Dev. Biol.2017; 5(47). DOI: 10.3389/fcell.2017.00047

  

Oldies but Goldies

 Kuss P, Kraft K, Stumm J, Ibrahim D, Vallecillo-Garcia P, Mundlos S, Stricker S. Regulation of Cell Polarity in the Cartilage Growth Plate and Perichondrium of Metacarpal Elements by HOXD13 and WNT5A. Dev. Biol. 2014; 385(1), 83-93. DOI: 10.1016/j.ydbio.2013.10.013

 Sartori R, Schirwis E, Blaauw B, Bortolanza S, Zhao J, Enzo E, Stantzou A, Mouisel E, Toniolo L, Ferry A, Stricker S, Goldberg AL, Dupont S, Piccolo S, Amthor H, Sandri M. BMP signaling controls muscle mass. Nat. Genet. 2013; 45(11), 1309-1318. DOI: 10.1038/ng.2772

 Stricker S, Mathia S, Haupt J, Seemann P, Meier J, Mundlos S. Odd-skipped related genes regulate differentiation of embryonic limb mesenchyme and bone marrow mesenchymal stromal cells. Stem Cells Dev. 2012; 21(4), 623-633. DOI: 10.1089/scd.2011.0154

 Kossler N*, Stricker S*, Rödelsperger C, Robinson PN Kim J, Dietrich C, Osswald M, Kühnisch J, Stevenson DA, Braun T, Mundlos S, Kolanczyk M. Neurofibromin (Nf1) is required for skeletal muscle development. Hum. Mol. Genet. 2011; 20(14), 2697-2709. DOI: 10.1093/hmg/ddr149 *co-first authors

 Witte F, Chan D, Economides AN, Mundlos S, Stricker S. Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region. Proc. Natl. Acad. Sci. U.S.A. 2010; 107(32), 14211-14216 DOI: 10.1073/pnas.1009314107

 Witte F, Bernatik O, Kirchner K, Masek J, Mahl A, Krejci P, Mundlos S, Schambony A, Bryja V, Stricker S. Negative regulation of Wnt signaling by CK1-phosphorylated Dishevelled via Ror2. FASEB J. 2010; 24, 2417-2426 DOI: 10.1096/fj.09-150615

 Schwarzer W, Witte F, Rajab A, Mundlos S, Stricker S. A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes. Hum. Mol. Genet. 2009; 18(21), 4013-4021 DOI: 10.1093/hmg/ddp345

 Kurth I, Klopocki E, Stricker S, van Oosterwijk J, Vanek S, Altmann J, van Harssel J, de Ravel T, Wilkie A, Gal A, Mundlos S. Duplications of non-coding elements 5´ of SOX9 are associated with brachydactyly/anonychia. Nat. Genet. 2009; 41(8), 862-863 DOI: 10.1038/ng0809-862

 Gao B, Hu J, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L, Cheah KSE, Chan D. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 2009; 458(7242), 1196-1201 DOI: 10.1038/nature07862

 Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S. Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expr. Patterns 2009; 9, 215-223 DOI: 10.1016/j.gep.2008.12.009

         awarded “Top 10 cited article 2008 – 2010”; awarded “Top 5 cited article 2009 - 2013”

 Michalk A*, Stricker S*, Becker J, Rupps R, Pantzar T, Miertus J, Botta G, Naretto VG, Janetzki C, Yaqoob N, Ott CE, Seelow D, Wieczorek D, Fiebig B, Wirth B, Hoopmann M, Walther M, Körber F, Blankenburg M, Mundlos S, Heller R, Hoffmann K. Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders. Am. J. Hum. Genet. 2008; 82(2), 464-476 DOI: 10.1016/j.ajhg.2007.11.006    *co-first authors