Recent Publications

Wei X, Rigopoulos A, Lienhard M, Pöhle-Kronawitter S, Kotsaris G, Franke G, Berndt N, Mejedo JO, Wu H, Börno S, Timmermann B, Murgai A, Glauben R, Stricker S. Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors. Nat. Commun. 2024, 15(1393). DOI: 10.1038/s41467-024-45618

Kotsaris G, Qazi TH, Bucher CH, Zahid H, Pöhle-Kronawitter S, Ugorets V, Jarassier W, Börno S, Timmermann B, Giesecke-Thiel C, Economides AN, Le Grand F, Vallecillo-García P, Knaus P, Geissler S and Stricker S. Odd skipped-related 1 controls the pro-regenerative response of Fibro-Adipogenic Progenitors. NPJ Regenerative Medicine 2023 8(19). DOI: 10.1038/s41536-023-00291-6 

Wei X, Lienhard M, Murgai A, Franke J, Pöhle-Kronawitter S, Kotsaris G, Wu H, Börno S, Timmermann B, Glauben R, and Stricker S. Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of juvenile myogenic progenitors. Preprint on bioRxiv 2021 https://doi.org/10.1101/2021.09.28.462168

 

Biferali B, Bianconi V, Perez DF, Pöhle-Kronawitter S, Marullo F, Maggio R, Santini T, Polverino F, Biagioni S, Summa V, Toniatti C, Pasini D, Stricker S, Di Fabio R, Chiacchiera F, Peruzzi G, Mozzetta C. Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair. Sci Adv. 2021; 7(23):eabd9371. DOI: 10.1126/sciadv.abd9371

 

Comai GE, Tesařová M, Dupé V, Rhinn M, Vallecillo-García P, da Silva F, Feret B, Exelby K, Dollé P, Carlsson L, Pryce B, Spitz F, Stricker S, Zikmund T, Kaiser J, Briscoe J, Schedl A, Ghyselinck NB, Schweitzer R, Tajbakhsh S. Local retinoic acid signaling directs emergence of the extraocular muscle functional unit. PLoS Biol. 2020; Nov 17; 18(11):e3000902. DOI: 10.1371/journal.pbio.3000902

 

Wei X, Franke J, Ost M, Wardelmann K, Börno S, Timmermann B, Meierhofer D, Kleinridders A, Klaus S, Stricker S. Cell autonomous requirement of Neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis. Journal of Cachexia, Sarcopenia and Muscle, 2020; 11, 1758-1778 DOI: 10.1002/jcsm.12632

 

Feng C, Chan WCW, Lam Y, Wang X, Chen P, Niu B, Ng VCW, Yeo JC, Stricker S, Cheah KSE, Koch M, Mundlos S, Ng HH, Chan D. Lgr5 and Col22a1 Mark Progenitor Cells in the Lineage toward Juvenile Articular Chondrocytes. Stem Cell Rep. 2019; 13(4), 713-29 DOI: 10.1016/j.stemcr.2019.08.006

 

Stumm J, Vallecilo-Garcia P, vom Hofe-Schneider S, Ollitrault D, Schrewe H, Economides AN, Marazzi G, Sassoon D, Stricker S. Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury. Stem Cell Res. 2018; 32, 8-16 DOI: 10.1016/j.scr.2018.08.010

 

Murgai A, Altmeyer S, Wiegand S, Tylzanowski P, Stricker S. Cooperation of BMP and IHH signaling in interdigital cell fate determination. PLoS ONE 2018; 13(5), e0197535. DOI: 10.1371/journal.pone.0197535

 

Orgeur M, Martens M, Leonte G, Nassari S, Bonnin MA, Börno ST, Timmermann B, Hecht J, Duprez D, Stricker S. Genome-wide strategies identify downstream target genes of connective tissue-associated transcription factors. Development 2018; 145, dev161208 DOI: 10.1242/dev.161208

 

Orgeur M, Martens M, Börno ST, Timmermann B, Duprez D, Stricker S. A dual transcript-discovery approach to improve the delimitation of gene features from RNA-seq data in the chicken model. Biol. Open 2018; 7, bio028498 DOI: 10.1242/bio.028498

 

Nassari S, Blavet S, Bonnin M-A, Stricker S, Duprez D, Fournier-Thibault C. The chemokines CXCL12 and CXCL14 differentially regulate connective tissue markers during limb development. Sci. Rep. 2017; 7(1), 17279. DOI: 10.1038/s41598-017-17490-z

 

Vallecillo García P, Orgeur M, Vom Hofe-Schneider S, Stumm J, Kappert V, Ibrahim DM, Börno ST, Hayashi S, Relaix F, Hildebrandt K, Sengle G, Koch M, Timmermann B, Marazzi G, Sassoon DA, Duprez D, Stricker S. Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development. Nat. Commun. 2017; 8:1218.DOI: 10.1038/s41467-017-01120-3

Dörpholz G, Murgai A, Jatzlau J, Horbelt D, Belverdi MP, Heroven C, Schreiber I, Wendel G, Ruschke K, Stricker S, Knaus P. IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation. Sci. Rep. 2017; 7(1), 8778. DOI: 10.1038/s41598-017-08676-6

Bernatik O, Radaskiewicz T, Behal M, Dave Z, Witte F, Mahl A, Cernohorsky NH, Krejci P, Stricker S, Bryja V. A novel role for the BMP antagonist Noggin in sensitizing cells to non-canonical Wnt-5a/Ror2/Dishevelled pathway activation. Front. Cell Dev. Biol. 2017; 5(47). DOI: 10.3389/fcell.2017.00047

  

 

Oldies but Goldies

 

 Kuss P, Kraft K, Stumm J, Ibrahim D, Vallecillo-Garcia P, Mundlos S, Stricker S. Regulation of Cell Polarity in the Cartilage Growth Plate and Perichondrium of Metacarpal Elements by HOXD13 and WNT5A. Dev. Biol. 2014; 385(1), 83-93. DOI: 10.1016/j.ydbio.2013.10.013

 

Sartori R, Schirwis E, Blaauw B, Bortolanza S, Zhao J, Enzo E, Stantzou A, Mouisel E, Toniolo L, Ferry A, Stricker S, Goldberg AL, Dupont S, Piccolo S, Amthor H, Sandri M. BMP signaling controls muscle mass. Nat. Genet. 2013; 45(11), 1309-1318. DOI: 10.1038/ng.2772

 

Stricker S, Mathia S, Haupt J, Seemann P, Meier J, Mundlos S. Odd-skipped related genes regulate differentiation of embryonic limb mesenchyme and bone marrow mesenchymal stromal cells. Stem Cells Dev. 2012; 21(4), 623-633. DOI: 10.1089/scd.2011.0154

 

Kossler N*, Stricker S*, Rödelsperger C, Robinson PN Kim J, Dietrich C, Osswald M, Kühnisch J, Stevenson DA, Braun T, Mundlos S, Kolanczyk M. Neurofibromin (Nf1) is required for skeletal muscle development. Hum. Mol. Genet. 2011; 20(14), 2697-2709. DOI: 10.1093/hmg/ddr149 *co-first authors

 

Witte F, Chan D, Economides AN, Mundlos S, Stricker S. Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region. Proc. Natl. Acad. Sci. U.S.A. 2010; 107(32), 14211-14216 DOI: 10.1073/pnas.1009314107

 

Witte F, Bernatik O, Kirchner K, Masek J, Mahl A, Krejci P, Mundlos S, Schambony A, Bryja V, Stricker S. Negative regulation of Wnt signaling by CK1-phosphorylated Dishevelled via Ror2. FASEB J. 2010; 24, 2417-2426 DOI: 10.1096/fj.09-150615

 

Schwarzer W, Witte F, Rajab A, Mundlos S, Stricker S. A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes. Hum. Mol. Genet. 2009; 18(21), 4013-4021 DOI: 10.1093/hmg/ddp345

 

Kurth I, Klopocki E, Stricker S, van Oosterwijk J, Vanek S, Altmann J, van Harssel J, de Ravel T, Wilkie A, Gal A, Mundlos S. Duplications of non-coding elements 5´ of SOX9 are associated with brachydactyly/anonychia. Nat. Genet. 2009; 41(8), 862-863 DOI: 10.1038/ng0809-862

 

Gao B, Hu J, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L, Cheah KSE, Chan D. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 2009; 458(7242), 1196-1201 DOI: 10.1038/nature07862

 

Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S. Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expr. Patterns 2009; 9, 215-223 DOI: 10.1016/j.gep.2008.12.009

         awarded “Top 10 cited article 2008 – 2010”; awarded “Top 5 cited article 2009 - 2013”

 

Michalk A*, Stricker S*, Becker J, Rupps R, Pantzar T, Miertus J, Botta G, Naretto VG, Janetzki C, Yaqoob N, Ott CE, Seelow D, Wieczorek D, Fiebig B, Wirth B, Hoopmann M, Walther M, Körber F, Blankenburg M, Mundlos S, Heller R, Hoffmann K. Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders. Am. J. Hum. Genet. 2008; 82(2), 464-476 DOI: 10.1016/j.ajhg.2007.11.006    *co-first authors

 

  

 

Reviews and Book chapters

 

Helmbacher F, Stricker S. Tissue cross talks governing limb muscle development and regeneration. Sem. Cell Dev. Biol. 2020; 4, 14-30 DOI: 10.1016/j.semcdb.2020.05.005

 

Stricker S, Rauschenberger V, Schambony A. ROR Family Receptor Tyrosine Kinases. In: Andreas Jenny, editor: Curr. Top. Dev. Biol. Vol. 123 (Protein Kinases in Development and Disease), Burlington: Academic Press, 2017; 105-142 DOI: 10.1016/bs.ctdb.2016.09.003

 

Stricker S, Knaus P, Simon HG. Putting Cells into Context. Front. Cell. Dev. Biol. 2017; 5(32), DOI: 10.3389/fcell.2017.00032

 

Spielmann M and Stricker S. Limb Development. In: Inborn Errors of Development (Ed. R.P. Erickson, A. Wynshaw-Boris), Third Edition, Oxford University Press 2016; pp147-160

 

Stricker S and Mundlos S. Development of the Limbs. In: Limb Malformations (S. Mundlos, D. Horn), Springer Verlag Berlin Heidelberg, 2014; pp2-9

 

Stricker S, Mundlos S. FGF and ROR2 receptor tyrosine kinase signaling in human skeletal development. In: Carmen Birchmeier, editor: Curr. Top. Dev. Biol. Vol. 97 (Growth Factors in Development), Burlington: Academic Press, 2011; pp179-206

 

Stricker S, Mundlos S. Mechanisms of digit formation: human malformation syndromes tell the story. Dev. Dyn. (Special issue “limb development” Ed. J. F. Fallon) 2011; 240(5), 990-1004