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Publications

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Selected Original Publications

  • He H, Guzman RE, Cao D, Sierra-Marquez J, Yin F, Fahlke C, Peng J, Stauber T (2021) The molecular and phenotypic spectrum of CLCN4-related epilepsy. Epilepsia, epub ahead of print. DOI: 10.1111/epi.16906

  • Chen L, König B, Stauber T (2020) LRRC8 channel activation and reduction in cytosolic chloride concentration during early differentiation of C2C12 myoblasts. Biochem Biophys Res Commun, 532: 482-488. https://doi.org/10.1016/j.bbrc.2020.08.080

  • Pervaiz S, Kopp A, von Kleist L, Stauber T (2019) Absolute Protein Amounts and Relative Abundance of Volume-regulated Anion Channel (VRAC) LRRC8 Subunits in Cells and Tissues Revealed by Quantitative Immunoblotting. Int J Mol Sci, 20: E5879. https://doi.org/10.3390/ijms20235879

  • Astaburuaga R, Quintanar Haro OD, Stauber T*, Relógio A* (2019) A Mathematical Model of Lysosomal Ion Homeostasis Points to Differential Effects of Cl- Transport in Ca2+ Dynamics. Cells, 8: E1263. *corresponding authors. doi: 10.3390/cells8101263

  • Chen L, Becker TM, Koch U and Stauber T (2019) The LRRC8/VRAC anion channel facilitates myogenic differentiation of murine myoblasts by promoting membrane hyperpolarization. J Biol Chem, 294:14279-14288. doi: 10.1074/jbc.RA119.008840

  • König B, Hao Y, Schwartz S, Plested AJR and Stauber T (2019) A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength. Elife, 8: e45421. doi: 10.7554/eLife.45421

  • Liu T and Stauber T (2019) The Volume-Regulated Anion Channel LRRC8/VRAC Is Dispensable for Cell Proliferation and Migration. Int J Mol Sci, 20: E2663. https://doi.org/10.3390/ijms20112663

  • Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N, Andrade-Navarro MA, von Kries JP, Stauber T*, Jentsch TJ* (2014) Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science, 344: 634-638. *corresponding authors

  • Leisle L, Ludwig CF, Wagner FA, Jentsch TJ and Stauber T (2011) ClC-7 is a slowly voltage-gated 2Cl-/1H+-exchanger and requires Ostm1 for transport activity. EMBO J, 30: 2140-2152.

  • Stauber T and Jentsch TJ (2010) Sorting motifs of the endosomal/lysosomal CLC chloride transporters. J Biol Chem, 285: 34537-34548.

  • Weinert S, Jabs S, Supanchart C, Schweizer M, Gimber N, Richter M, Rademann J, Stauber T, Kornak U and Jentsch TJ (2010) Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation. Science, 328: 1401-1403.

  • Steinberg BE, Huynh KK, Brodovitch A, Jabs S, Stauber T, Jentsch TJ and Grinstein S (2010) A cation counterflux supports lysosomal acidification. J Cell Biol, 189: 1171-1186.

  • Stauber T, Simpson JC, Pepperkok R and Vernos I (2006) A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex. Curr Biol, 16: 2245-2251.

Selected Reviews

  • Bose S, He H and Stauber T (2021) Neurodegeneration upon dysfunction of endosomal/lysosomal CLC chloride transporters. Front Cell Dev Biol, 9:639231. doi: 10.3389/fcell.2021.639231

  • Chen L, König B, Liu T, Pervaiz S, Razzaque YS and Stauber T (2019) More than just a pressure relief valve: physiological roles of volume-regulated LRRC8 anion channels. Biol Chem, 400:1481-1496. doi: 10.1515/hsz-2019-0189

  • König B and Stauber T (2019) Biophysics and structure-function relationships of LRRC8-formed volume-regulated anion channels. Biophys J, 116:1185-1193. doi: 10.1016/j.bpj.2019.02.014.

  • Stauber T (2015) The volume-regulated anion channel is formed by LRRC8 heteromers - molecular identification and roles in membrane transport and physiology. Biol Chem, 396: 975-990.

  • Stauber T and Jentsch TJ (2013) Chloride in vesicular trafficking and function. Annu Rev Physiol, 75: 453-477.

  • Stauber T, Weinert S and Jentsch TJ (2012) Cell biology and physiology of CLC chloride channels and transporters. Compr Physiol, 2: 1701-1744.