Publications

For a complete publication list, click here.

Selected Original Publications

  • Chen L, Becker TM, Koch U and Stauber T (2019) The LRRC8/VRAC anion channel facilitates myogenic differentiation of murine myoblasts by promoting membrane hyperpolarization. J Biol Chem, electronic prepub doi: 10.1074/jbc.RA119.008840

  • König B, Hao Y, Schwartz S, Plested AJR and Stauber T (2019) A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength. Elife, 8: e45421. doi: 10.7554/eLife.45421

  • Liu T and Stauber T (2019) The Volume-Regulated Anion Channel LRRC8/VRAC Is Dispensable for Cell Proliferation and Migration. Int J Mol Sci, 20: E2663. https://doi.org/10.3390/ijms20112663

  • von Kleist L, Ariunbat K, Braren I, Stauber T, Storch S, Danyukova T (2019) A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival. Mol Genet Metab, 126:196-205.

  • Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N, Andrade-Navarro MA, von Kries JP, Stauber T*, Jentsch TJ* (2014) Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science, 344: 634-638. *corresponding authors

  • Sartelet A*, Stauber T*, Coppieters W, Ludwig CF, Fasquelle C, Druet T, Zhang Z, Ahariz N, Cambisano N, Jentsch TJ, and Charlier C (2014) A missense mutation accelerating the gating of the lysosomal Cl-/H+ exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle. Dis Model Mech, 7: 119-128. *contributed equally

  • Leisle L, Ludwig CF, Wagner FA, Jentsch TJ and Stauber T (2011) ClC-7 is a slowly voltage-gated 2Cl-/1H+-exchanger and requires Ostm1 for transport activity. EMBO J, 30: 2140-2152.

  • Stauber T and Jentsch TJ (2010) Sorting motifs of the endosomal/lysosomal CLC chloride transporters. J Biol Chem, 285: 34537-34548.

  • Weinert S, Jabs S, Supanchart C, Schweizer M, Gimber N, Richter M, Rademann J, Stauber T, Kornak U and Jentsch TJ (2010) Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation. Science, 328: 1401-1403.

  • Steinberg BE, Huynh KK, Brodovitch A, Jabs S, Stauber T, Jentsch TJ and Grinstein S (2010) A cation counterflux supports lysosomal acidification. J Cell Biol, 189: 1171-1186.

  • Stauber T, Simpson JC, Pepperkok R and Vernos I (2006) A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex. Curr Biol, 16: 2245-2251.

Selected Reviews

  • Chen L, König B, Liu T, Pervaiz S, Razzaque YS and Stauber T (2019) More than just a pressure release valve: physiological roles of volume-regulated LRRC8 anion channels. Biol Chem. pii: /j/bchm.just-accepted/hsz-2019-0189/hsz-2019-0189.xml. doi: 10.1515/hsz-2019-0189

  • König B and Stauber T (2019) Biophysics and structure-function relationships of LRRC8-formed volume-regulated anion channels. Biophys J, 116:1185-1193. doi: 10.1016/j.bpj.2019.02.014.

  • Stauber T (2015) The volume-regulated anion channel is formed by LRRC8 heteromers - molecular identification and roles in membrane transport and physiology. Biol Chem, 396: 975-990.

  • Stauber T and Jentsch TJ (2013) Chloride in vesicular trafficking and function. Annu Rev Physiol, 75: 453-477.

  • Stauber T, Weinert S and Jentsch TJ (2012) Cell biology and physiology of CLC chloride channels and transporters. Compr Physiol, 2: 1701-1744.

  • Wartosch L and Stauber T (2010) A role for chloride transport in lysosomal protein degradation. Autophagy, 6: 158-159.