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Prof. Dr. Tobias Stauber



Group leader

Thielallee 63
Room 117B
D-14195 Berlin
+49 30 838-454069
Original Publications
  • Pervaiz S, Kopp A, von Kleist L, Stauber T (2019) Absolute Protein Amounts and Relative Abundance of Volume-regulated Anion Channel (VRAC) LRRC8 Subunits in Cells and Tissues Revealed by Quantitative Immunoblotting. Int J Mol Sci, 20: E5879. https://doi.org/10.3390/ijms20235879

  • Astaburuaga R, Quintanar Haro OD, Stauber T*, Relógio A* (2019) A Mathematical Model of Lysosomal Ion Homeostasis Points to Differential Effects of Cl- Transport in Ca2+ Dynamics. Cells, 8: E1263. *corresponding authors. doi: 10.3390/cells8101263

  • Chen L, Becker TM, Koch U and Stauber T (2019) The LRRC8/VRAC anion channel facilitates myogenic differentiation of murine myoblasts by promoting membrane hyperpolarization. J Biol Chem, 294:14279-14288. doi: 10.1074/jbc.RA119.008840

  • König B, Hao Y, Schwartz S, Plested AJR and Stauber T (2019) A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength. Elife, 8: e45421. doi: 10.7554/eLife.45421

  • Liu T and Stauber T (2019) The Volume-Regulated Anion Channel LRRC8/VRAC Is Dispensable for Cell Proliferation and Migration. Int J Mol Sci, 20: E2663. https://doi.org/10.3390/ijms20112663

  • Khundadze M, Ribaudo F, Hussain A, Rosentreter J, Nietzsche S, Thelen M, Winter D, Hoffmann B, Afzal MA, Hermann T, de Heus C, Piskor EM, Kosan C, Franzka P, von Kleist L, Stauber T, Klumperman J, Damme M, Proikas-Cezanne T, Hübner CA (2019) A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five. Neurobiol Dis, 127:419-431.

  • von Kleist L, Ariunbat K, Braren I, Stauber T, Storch S, Danyukova T (2019) A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival. Mol Genet Metab, 126:196-205.

  • Ullrich F, Reincke SM, Voss FK, Stauber T, Jentsch TJ (2016) Inactivation kinetics and anion selectivity of volume-regulated anion channels (VRACs) depend on C-terminal residues of the first extracellular loop. J Biol Chem, 291: 17040-17048.

  • Planells-Cases R, Lutter D, Guyader C, Gerhards NM, Ullrich F, Elger DA, Kucukosmanoglu A, Xu G, Voss FK, Reincke SM, Stauber T, Blomen VA, Vis DJ, Wessels LF, Brummelkamp TR, Borst P, Rottenberg S, Jentsch TJ (2015) Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. EMBO Journal, 34: 2993-3008.

  • Varga RE, Khundadze M, Damme M, Nietzsche S, Hoffmann B, Stauber T, Koch N, Hennings JC, Franzka P, Huebner AK, Kessels MM, Biskup C, Jentsch TJ, Qualmann B, Braulke T, Kurth I, Beetz C, Hübner CA (2015) In vivo evidence for lysosome depletion and impaired autophagic clearance in hereditary spastic paraplegia Type SPG11. PLoS Genet, 11: e1005454

  • Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N, Andrade-Navarro MA, von Kries JP, Stauber T*, Jentsch TJ* (2014) Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science, 344: 634-638. *corresponding authors

  • Sartelet A*, Stauber T*, Coppieters W, Ludwig CF, Fasquelle C, Druet T, Zhang Z, Ahariz N, Cambisano N, Jentsch TJ, and Charlier C (2014) A missense mutation accelerating the gating of the lysosomal Cl-/H+ exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle. Dis Model Mech, 7: 119-128. *contributed equally

  • Barvencik F, Kurth I, Koehne T, Stauber T, Zustin J, Tsiakas K, Ludwig CF, Beil FT, Pestka JM, Hahn M, Santer R, Supanchart C, Kornak U, Del Fattore A, Jentsch TJ, Teti A, Schulz A, Schinke T, Amling A (2014) CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals. J Bone Miner Res, 29: 982-991.

  • Ludwig CF, Ullrich F, Leisle L, Stauber T, Jentsch TJ (2013) Common gating of both CLC subunits underlies voltage-dependent activation of the 2Cl–/1H+-exchanger ClC 7/Ostm1. J Biol Chem, 288: 28611-28619.

  • Hennings JC, Picard N, Huebner AK, Stauber T, Maier H, Brown D, Jentsch TJ, Vargas-Poussou R, Eladari D and Hübner CA (2012) A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule. EMBO Mol Med, 4: 1057-1071.

  • Leisle L, Ludwig CF, Wagner FA, Jentsch TJ and Stauber T (2011) ClC-7 is a slowly voltage-gated 2Cl-/1H+-exchanger and requires Ostm1 for transport activity. EMBO J, 30: 2140-2152.

  • Stauber T and Jentsch TJ (2010) Sorting motifs of the endosomal/lysosomal CLC chloride transporters. J Biol Chem, 285: 34537-34548.

  • Schulz P, Werner J, Stauber T, Henriksen K and Fendler K (2010) The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One, 5: e12585.

  • Weinert S, Jabs S, Supanchart C, Schweizer M, Gimber N, Richter M, Rademann J, Stauber T, Kornak U and Jentsch TJ (2010) Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation. Science, 328: 1401-1403.

  • Steinberg BE, Huynh KK, Brodovitch A, Jabs S, Stauber T, Jentsch TJ and Grinstein S (2010) A cation counterflux supports lysosomal acidification. J Cell Biol, 189: 1171-1186.

  • Neagoe I, Stauber T, Fidzinski P, Bergsdorf EY and Jentsch TJ (2010) The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression. J Biol Chem, 285: 21689-21697.

  • Pressey SN, O'Donnell KJ, Stauber T, Fuhrmann JC, Tyynela J, Jentsch TJ and Cooper JD (2010) Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7/Ostm1. J Neuropathol Exp Neurol, 69: 1228-1246.

  • Wartosch L, Fuhrmann JC, Schweizer M, Stauber T and Jentsch TJ (2009) Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7. FASEB J, 23: 4056-4068.

  • Schepis A, Stauber T and Krijnse Locker J (2007) Kinesin-1 plays multiple roles during the vaccinia virus life cycle. Cell Microbiol, 9: 1960-1973.

  • Stauber T, Simpson JC, Pepperkok R and Vernos I (2006) A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex. Curr Biol, 16: 2245-2251.

  • Young J, Stauber T, del Nery E, Vernos I, Pepperkok R and Nilsson T (2005) Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A'. Mol Biol Cell, 16: 162-177.

  • Brown CL, Maier KC, Stauber T, Ginkel LM, Wordeman L, Vernos I and Schroer TA (2005) Kinesin-2 is a motor for late endosomes and lysosomes. Traffic, 6: 1114-1124.


Reviews and Editorials
  • Chen L, König B, Liu T, Pervaiz S, Razzaque YS and Stauber T (2019) More than just a pressure relief valve: physiological roles of volume-regulated LRRC8 anion channels. Biol Chem. 400:1481-1496. doi: 10.1515/hsz-2019-0189

  • König B and Stauber T (2019) Biophysics and structure-function relationships of LRRC8-formed volume-regulated anion channels. Biophys J, 116:1185-1193. doi: 10.1016/j.bpj.2019.02.014

  • Stauber T (2015) The volume-regulated anion channel is formed by LRRC8 heteromers - molecular identification and roles in membrane transport and physiology. Biol Chem, 396: 975-990.

  • Stauber T, Horn D and Kornak U (2013) Monogenic ion channelopathies of the skeleton. Med Genetik, 25: 493-500. (in German)

  • Stauber T and Jentsch TJ (2013) Chloride in vesicular trafficking and function. Annu Rev Physiol, 75: 453-477.

  • Stauber T, Weinert S and Jentsch TJ (2012) Cell biology and physiology of CLC chloride channels and transporters. Compr Physiol, 2: 1701-1744.

  • Wartosch L and Stauber T (2010) A role for chloride transport in lysosomal protein degradation. Autophagy, 6: 158-159.


Book Chapters
  • König B, von Kleist L and Stauber T (2017). Measurement of lysosomal ion homeostasis by fluorescence microscopy. In Sanches J, Seruca R and Suri J (eds) Imaging and biological quantification, pp. 259-278.

  • Stauber T, Novarino G and Jentsch TJ (2009). The CLC family of chloride channels and transporters. In Alvarez-Leefmans FJ and Delpire E (eds) Physiology and pathology of chloride transporters and channels in the nervous system: from molecules to diseases, pp. 205-227.

  • Ostermann J, Stauber T and Nilsson T (2002) Vesicular transport. In Dalbey RE and von Heijne G (eds) Protein targeting, transport and tanslocation, pp. 377-401.