Selected Publications
Preußner M*, Smith HL, Hughes D, Zhang M, Emmerichs AK, Scalzitti S, Peretti D, Swinden D, Neumann A, Haltenhof T, Mallucci GR*, Heyd F* (2023) ASO targeting RBM3 temperature-controlled poison exon splicing prevents neurodegeneration in vivo. EMBO Mol Med. 22, e17157
Dybkov O, Preußner M*, El Ayoubi L, Feng VY, Harnisch C, Merz K, Leupold P, Yudichev P, Agafonov DE, Will CL, Girard C, Dienemann C, Urlaub H, Kastner B, Heyd F*, Lührmann R* (2023) Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins. Sci Adv. 9, eadf1785
Los B, Preußner M, Eschke K, Vidal RM, Abdelgawad A, Olofsson D, Keiper S, Paulo-Pedro M, Grindel A, Meinke S, Trimpert J, Heyd F (2022) Body temperature variation controls pre-mRNA processing and transcription of antiviral genes and SARS-CoV-2 replication. Nucleic Acids Res. 50, 6769-6785
Neumann A, Meinke S, Goldammer G, Strauch M, Schubert M, Timmermann B, Heyd F*, Preußner M* (2020) Alternative splicing coupled mRNA decay shapes the temperature-dependent transcriptome. EMBO Rep 21, e51369
Haltenhof T, Kotte A, De Bortoli F, Schiefer S, Meinke S, Emmerichs AK, Petermann KK, Timmermann B, Imhof P, Franz A, Loll B, Wahl MC, Preußner M, Heyd F (2020) A Conserved Kinase-Based Body-Temperature Sensor Globally Controls Alternative Splicing and Gene Expression. Mol Cell 78, 57-69
Neumann A, Schindler M, Olofsson D, Wilhelmi I, Schürmann A, Heyd F (2019) Genome-wide identification of alternative splicing events that regulate protein transport across the secretory pathway. J Cell Sci 2019, doi: 10.1242/jcs.230201
Preußner M, Goldammer G, Neumann A, Haltenhof T, Rautenstrauch P, Müller-McNicoll M, Heyd F (2017) Body temperature cycles control rhythmic alternative splicing in mammals. Mol Cell. 67, 433-446
Wilhelmi I, Kanski R, Neumann A, Herdt O, Hoff F, Jacob R, Preussner M, Heyd F (2016) Sec16 alternative splicing dynamically controls COPII transport efficiency. Nat Commun. 7, 12347